糖皮质激素在重症肺炎中的辅助治疗作用

Adjuvant role of corticosteroids in the treatment of severe community-acquired pneumonia

重症社区获得性肺炎（severe community—acquired pneumonia，SCAP）是一种常见疾病，尽管目前临床诊断、治疗等已取得了很大进步，但其住院率及病死率仍居高不下。本综述简述了SCAP的炎症反应机制、糖皮质激素在炎症反应中的作用及其在重症肺炎治疗中的进展，并就治疗方面一直存在的争议进行了探讨，提出了糖皮质激素在重症肺炎综合治疗中的作用已日渐突出，且短疗程、小剂量应用糖皮质激素是有利的。

Severe community-acquired pneumonia is a common disease. Despite great advances in clinical diagnosis and treatment, the hospitalization rate and mortality among patients with SCAP keep high. The review describes the mechanism of inflammatory reaction, effect of glueocorticoid in inflammatory reaction and development of treatment in severe community-acquired pneumonia. The use of glueocorticoid in treatment has always been controversial, but the role of glucocorticoid has been more and more prominent. The short-duration and lowdose glucocorticoid during severe community-acquired pneumonia is benefit.