PI3K信号通路在急性胰腺炎发病机制中的研究进展

Role of phosphoinositide-3 kinase signaling pathways in pathogenesis of acute pancreatitis

急性胰腺炎(acute pancreatitis,AP)作为临床上常见的急性病症之一,对人们健康的危害性极大.调查显示约1/5的病例会发展至急性呼吸窘迫综合征和多器官功能障碍阶段,伴随高死亡率.早期学者们对该病发病机制的认识仅限于胰酶在胰腺内被异常激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应.近年来,随着医学界对该病重视程度的增高,研究逐渐深入,方向集中于其发病过程中的免疫炎症反应,以下对其中研究比较热门的磷脂酰肌醇-3激酶信号通路与AP免疫炎症之间的关系作一阐述.

Acute pancreatitis（AP） as a common acute disease poses a great threat to people＇s health.According to statistics,about onefifth of cases develop acute respiratory distress syndrome and multiple organ dysfunction,which result in high mortality.The early understanding of the pathogenesis of this disease is limited to an inflammatory response resulting in autodigestion,edema,hemorrhage and necrosis of pancreatic tissue after the abnormal activation of trypsin.In recent years,researchers have focused their research on the role of immune inflammatory response in the pathogenesis of AP.Here we discuss the relationship between the immune inflammation and PI3 K signaling pathways in AP.