血清sST-2与2型糖尿病患者冠状动脉斑块的相关性研究

The relationships between serum soluble ST2 levels and coronary atherosclerosis plaque in patients with type 2 diabetes mellitus

目的 探讨2型糖尿病患者血清可溶性人基质裂解素（s ST-2）与冠状动脉粥样硬化、斑块负荷和斑块结构之间的相关性。方法 行冠脉CTA检测的188例2型糖尿病患者,根据冠脉CTA结果分为非冠状动脉粥样硬化组93例和冠状动脉粥样硬化组95例,ELISA法检测患者血清s ST-2水平。结果 冠状动脉粥样硬化组患者血清s ST-2水平明显高于非冠状动脉硬化组（P〈0.05）,s ST-2与BMI、hs-CRP、斑块数目、病变血管/节段数目、斑块数量和钙化斑块呈正相关性（P〈0.05）;s ST-2水平是校正后2型糖尿病冠状动脉粥样硬化的独立预测因子（P〈0.05,OR为1.002,95%CI为1.000-1.003）。结论 s ST-2与2型糖尿病患者发生冠状动脉粥样硬化有相关性。

Objective To explore the relationship between serum soluble ST2 and coronary atherosclerosis,coronary plaque burden and plaque structures in patients with type 2 diabetes mellitus （DM）. Methods A total of 188 patients diagnosized type 2 DM undergoing planned coronary computed tomography angiography （CTA） were enrolled in this observational study. According to the CTA images,the patients were divided into non - coronary artery diseases group andcoronary artery diseases group. The level of sST2 were detected using ELISA kit. Results The sST-2 concentrations were significantly higher in the CAD group than in the non- CAD group（P 〈0. 05）. The levels of sST- 2 were correlated positively with BMI, high - sensitivity C -reactive protein, the total number of diseased vessels,the number of plaques and the calcified plaque type（P 〈0. 05）. sST -2 were found to be a significant independent predictor of coronary atherosclerosis in type 2 diabetic patients （P〈0.05;odds ratio , 1.002 ;95% confidence interval,1.000-1.003）. Condusions sST-2 is associated with coronary atherosclerosis in type 2 diabetic patients.