血清总胆汁酸水平在冠心病患者的变化及回归分析

The changes of total bile acid level in serumand logistic regression analysis in coronary heart disease(CHD) patients

目的探讨血清总胆汁酸水平与冠心病患者的关系。方法选取105例经冠状动脉造影确诊的冠心病患者作为冠心病组,选取同期住院的105例非冠心病患者作为对照组。收集临床资料并测定血清总胆汁酸及其他生物化学指标,探讨血清总胆汁酸在各组的表达水平,并通过多因素Logistic回归分析血清总胆汁酸与冠心病发生的相关性。结果冠心病组与对照组之间血清总胆汁酸水平比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,高水平血清总胆汁酸是冠心病发生的危险因素(P<0.05)。结论冠心病患者血清总胆汁酸水平显著升高,血清总胆汁酸可能是冠心病发生的危险因素。

Objective To investigate the relationship between the level of bile acid and coronary heart disease. Methods 105 CHD patients diagnosed by coronary arteriography examination were selected as coronary heart disease groupand another 105 cases of no -CHD patients were selected as control group in the same period of the hospital. The clinical datas were collected, meanwhile,the level of total bile acid and other related biochemical indexes were tested. Using the muhinomial logistic regression analysisto explore the corre- lation of the level of bile acid and risk factors in CHD. Results The levels of bile acidhad statistical was differences betweenCHD group and control group（ P 〈 0.05 ）. The multinomial logistic regression analysisshowed that thelevel of bile acid in serum was also an inde- pendent risk factor for CHD（P 〈0. 05）. Conclusion This study shows that the bile acid level in serum significantly increases in CHD patients and may be an independent risk factor for CHD.