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ROC曲线评价胸腔积液中5项指标在原发性肺癌中的诊断价值 被引量:1

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摘要 目的应用受试者工作特征曲线分析评价胸腔积液中癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)、神经元特异性烯醇化酶(NSE)和细胞角蛋白19片段(CYFRA21-1)在原发性肺癌并胸腔积液中的诊断价值。方法对177例经病理确诊的胸腔积液患者,按胸腔积液性质分为恶性胸腔积液组35例和良性胸腔积液组142例。采用电化学发光法同时检测2组患者胸腔积液中CEA、CA125、CA199、NSE和CYFRA21-1,对2组结果进行统计分析。计算CEA、CA125、CA199、NSE和CYFRA21-1诊断肺癌的ROC曲线下面积(AUC),最佳诊断界值、YOUDEN值及其在最佳诊断界值时的诊断敏感性、特异性。结果恶性胸腔积液组各肿瘤标志物水平均高于良性胸腔积液组(P<0.05),CEA、CA125、CA199、NSE和CYFRA21-1的ROC曲线下面积(AUC),分别达到0.986、0.660、0.772、0.766、0.800,CEA对于肺癌具有较高的诊断价值。CEA、CA125、CA199、NSE和CYFRA21-1诊断最佳界值,分别为5.215、847.9、8.69、13.31、32.5 ng/m L;CEA的YOUDEN指数最接近1,说明其诊断效果最佳。结论胸腔积液中肿瘤标志物的检测在原发性肺癌的诊断中有一定价值,其中胸腔积液中CEA检测对肺癌诊断具有较高的价值。
作者 何涛 崔洁
出处 《宁夏医学杂志》 CAS 2016年第7期657-660,共4页 Ningxia Medical Journal
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