阿托伐他汀联合丹参酮ⅡA磺酸钠注射液对冠心病患者心绞痛影响

Atorvastatin Combined with Danshen Ketone ⅡA Sulfonic Acid Sodium Injection in the Treatment of Angina Pectoris of Coronary Heart Disease

目的:观察阿托伐他汀联合丹参酮ⅡA磺酸钠注射液治疗冠心病心绞痛疗效,探讨其临床价值。方法:选择本院于2014年3月至2015年9月收治的92例患者作为研究对象,按照配对分组法分为两组,每组46例,对照组给予阿托伐他汀治疗,观察组给予阿托伐他汀联合丹参酮ⅡA磺酸钠注射液治疗,比较两组疗效。结果:观察组治疗总有效率为44例(95.7%),高于对照组35例(76.1%),差异具有统计学意义(P<0.05)。观察组心电图疗效总有效率为43例(93.5%),高于对照组34例(73.9%),差异具有统计学意义(P<0.05)。治疗后观察组TG、TC、LDL-C均低于对照组,HDL-C高于对照组,差异具有统计学意义(P<0.05)。治疗后观察组CK、CK-MB、LDH及HBDH水平均低于对照组,差异具有统计学意义(P<0.05)。结论:阿托伐他汀联合丹参酮ⅡA磺酸钠注射液治疗冠心病疗效较佳,心绞痛改善明显,具有重要临床价值。

Objective ： To observe the effect of atorvastatin combined with Danshen ketone ⅡA sulfonic acid sodium injection in the treatment of angina pectoris of coronary heart disease, and to explore its clinical value. Methods： 92 patients treated in our hospital from March 2014 to September 2015 were divided into two groups, with 46 cases in each group, the control group was treated with atorvastatin, the observation group was treated with atorvastatin combined with Danshen ketore ⅡA sulfonic acid sodium injection.The clinical effect of two groups were compared. Results：The total effective rate of observation group was 44 cases （95.7%）, which was higher than that in the control group 35 cases （76.1%） , P〈0.05. The total effective rate of ECG in the observation group was 43 cases （93.5%） which was significantly higher than that in the control group 34 cases （73.9%） , P〈0.05. After treatment, TC, LDL-C, TG of the observation group were lower than those in control group, HDL-C was higher than that the control group, the difference was statistically significant, P〈0.05. After treatment, CK, LDH, CK-MB and HBDH of the observation group were lower than those in the control group, P〈0.05. Conclusion： The effect of atorvastatin combined with Danshen ketore IIA sulfonic acid sodium injection in the treatment of coronary heart disease is better, and angina pectoris improved significantly, so it has important clinical value.