左乙拉西坦添加治疗青年难治性部分性癫痫患者的效果及对认知功能的影响

The Effect and the Influence on the Cognitive Function of Levetiracetam in Treatment of Young Patients With Refractory Partial Epilepsy

目的探讨左乙拉西坦添加对青年难治性部分性癫痫患者的治疗效果及认知功能的影响。方法 86例青年难治性部分性癫痫患者随机分为对照组和观察组,每组43例,对照组给予常规抗癫痫治疗,观察组则在此基础上加用左乙拉西坦治疗。对比两组的治疗有效率与认知功能评分。结果对照组和观察组有效率分别为46.5%和76.7%,差异具有统计学意义(P<0.05)。对照组和观察组Mo CA评分分别为(21.4±1.7)分和(27.9±1.6)分,组间差异有统计学意义(P<0.05)。结论左乙拉西坦添加治疗青年难治性部分性癫痫效果显著,患者认知功能可得到有效改善。

Objective To investigate the effect of levetiracetam on youth refractory epilepsy treatment function and cognitive part. Methods 86 cases of young patients with refractory partial epilepsy were randomly divided into control group and observation group, 43 cases in each group, control group given routine antiepileptic treatment, observation group, on the basis of treatment with left b rasching temple.Comparison of two groups of treatment efficient and cognitive function score. Results Efficient control group and observation group were 46.5% and 76.7%, has significant difference（P〈0.05）. Mo CA scores in the control group and observation group, respectively（21.4±1.7） and（27.9±1.6） and significant difference between groups（P〈0.05）. Conclusion Levetiracetam youth refractory partial epilepsy effect significantly, can effectively improve the cognitive function of patients.