郁乐疏合剂治疗24例帕金森病伴失眠患者的疗效观察

Curative Effect Observation on Treating 24 Cases of Parkinson's Disease With Insomnia by the Mixture of Yuleshu

目的通过郁乐疏合剂治疗24例帕金森病伴失眠患者的对照研究,观察其疗效性和安全性。方法将帕金森病的患者分为郁乐疏组和对照组,治疗1个月,观察治疗前后的匹兹堡睡眠指数评分以及不良反应,进行统计学处理。结果两组患者年龄、病程和睡眠在治疗前差异无统计学意义(P>0.05);郁乐疏组患者治疗后睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、睡眠药物、日间功能紊乱以及PSQI指数总分分别为(1.22±0.87)、(1.71±0.70)、(0.91±0.73)、(0.92±0.75)、(1.03±0.68)、(0.91±0.50)、(0.98±0.67)和(7.38±3.82),较治疗前改善(P<0.05),其中研究组治疗后催眠药物、日间功能紊乱两项评价指标优于对照组患者[(1.31±0.83)和(1.46±0.97)](P<0.05)。结论郁乐疏合剂能改善帕金森病患者的失眠,且安全性较好。

Objective Through yuleshu mixture treatment 24 cases of Parkinson＇s disease with comparative study of insomnia patients, to observe its efficacy and safety. Methods Patients with Parkinson＇s disease（PD） points as yuleshu group and control group, treatment for 1 month were observed before and after treatment of Pittsburgh sleep quality index score and adverse reactions, were statistically analyzed. Results Two groups of patients with age, duration of disease and sleep in the treatment of no significant difference（P〈0.05）. Yuleshu group of patients after treatment of sleep quality, sleep latency, sleep time, sleep efficiency, sleep disorders, sleep medication, and daytime dysfunction index PSQI scores were（1.22±0.87）,（1.71±0.70）,（0.91±0.73）,（0.92±0.75）,（1.03±0.68）,（0.91±0.50）,（0.98±0.67） and（7.38±3.82）, compared with before treatment significantly improved（P〈0.05）, in which the study group after treatment hypnotic drugs, two daytime dysfunction index was significantly better than the control group of patients [（1.31±0.83） and（1.46±0.97）]（P〈0.05）. Conclusion Yuleshu mixture can obviously improve the insomnia patients with Parkinson＇s disease, and good safety.