摘要
目的：探讨肝脏CT灌注成像中最大斜率算法（MS）和去卷积算法（DC）对灌注参数的影响。方法回顾性分析因临床需要进行了肝脏CTP检查，且图像质量较好的62例患者资料。患者均行320排容积CT肝脏CTP检查，并分别采用MS和DC法处理数据。由2名放射科医师采用双盲法对62个正常肝段及49个瘤灶（原发性肝癌25个、血管瘤20个、肝局灶性结节增生4个）进行分析，测得灌注参数值，包括血流量（BF），血容量（BV）和肝动脉门静脉灌注比值（PI）。采用组内相关系数（ICC）比较不同医师测量结果间一致性，采用配对t检验比较两种算法间所得各项CTP参数值的差异；采用Pearson线性相关分析评价各项CTP参数值间的相关性；采用Bland-Altman分析评价两种算法所得各项CTP参数值间的一致性。结果2名医师的测量结果一致性较好（ICC≥0.95）。正常肝段、原发性肝癌、血管瘤和肝局灶性结节增生的DC法BF、BV值均高于MS法参数，差异有统计学意义（P均〈0.05）；正常肝段DC法PI值高于MS法，差异有统计学意义（P均〈0.05）；肝肿瘤灶两种算法测量的PI值差异无统计学意义（P〉0.05）。两种算法所得BF、BV及PI结果间均具有良好的相关性（r值均〉0.9， P〈0.01）。两种算法测得的BF、BV和PI不一致。结论 MS和DC两种算法所测得BF、BV、PI等灌注参数值具有较好的相关性，但一致性不佳。
Objective To evaluate the reliability of CT perfusion parameter values of the normal hepatic segments and neoplasms, obtained with deconvolution （DC） and maximum slope （MS） algorithms. Methods Perfusion parameter values of 111 ROIs in 62 normal hepatic segments and 49 neoplasms derived from 62 CT perfusion studies performed with 320 multi-slice CT, were retrospectively analyzed by two experienced radiologists. BF,BV and PI according to DC and MS algorithms were compared with t paired test, Pearson correlation and Bland-Altman agreement analysis. Interobserver agreement for all perfusion parameters was calculated using intraclass correlation coefficients （ICC）. Results Interobserver agreement measured with ICC was very good for all perfusion parameters （≥0.95）. BFdc and BVdc exceeded the BFms and BVms in normal hepatic segments and neoplasms （P〈0.05）; PIdc significantly exceeded the PIms in normal hepatic segments（P〈0.05） ,while no difference were found in hepatic neoplasms（P〉0.05）. Both pairs of perfusion measurements significantly correlated with each other（r〉0.9, P〈0.01）,but the agreement of BF, BV and PI according to DC and MS algorithms was not good. Conclusions CT perfusion values such as BF,BV and PI obtained by DC and MS algorithms correlated significantly with each other, but with poor agreement.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2016年第7期537-541,共5页
Chinese Journal of Radiology
基金
温州市科技局基金（Y20140043）
