壳聚糖基抗菌型创伤敷料的研究进展

Progress in Chitosan-Based Antimicrobial Wound Dressing

近年来,随着再生医学的快速发展,组织工程技术再造人体组织器官被广泛的关注和研究。其中对加速创伤修复的敷料材料设计非常重要,其结构性质严重影响了再生组织的形态和效果。天然高分子壳聚糖具有广谱抗菌、强效止血作用,无毒性降解物,具有良好的生物相容性、生物活性和生物可降解性良好,能够有效地促进创面愈合和组织修复再生,在生物医用敷料领域具有广阔的应用前景。本文主要综述近年来壳聚糖基创伤敷料设计成型方法,并讨论不同的成型工艺及负载不同抗菌剂的敷料性能及用途差异。以期能够为设计和开发新型壳聚糖基抗菌型创伤敷料材料提供重要参考。

In recent years, with the development of regenerative medicine technique, there has been a heated attention and research about reconstruction of human organs by means of tissue engineering. One important factor of accelerate wound repair by designed dressing materials, which has significant impact on the structure and nature of regeneration tissue. Natural polymer chitosan （CS） has broad-spectrum antibacterial activity and powerful hemostatic function, non- harmful degradation products, has good biological compatibility, bioaetivity and bio-degradability, which can effectively promote wound healing and tissue repair and regeneration in the field of biomedical dressing has broad application prospects. This article mainly reviewed in recent years, chitosan wound dressing design molding methods, and discuss the dressing performance and usage of different molding processes and antibacterial agents. It may contribute us to effectively design and develop new types of chitosan-based antimicrobial wound repair material.