清热活血方对狼疮性肾炎热毒血瘀证患者血清PAF含量的影响

Effect of Qingre Huoxue Decoction on Serum PAF Level in Patients with Lupus Nephritis belonged to Noxious Heat Blood Stasis Syndrome

目的观察清热活血方结合西药治疗对狼疮性肾炎(LN)热毒血瘀证患者血清血小板活化因子(PAF)含量的影响。方法将42例患者随机分为2组,对照组20例,治疗组22例。治疗组采用清热活血方加激素治疗;对照组仅单纯采用激素治疗,连续用药1个月。分别在治疗前及治疗后1个月测定患者血清PAF含量和统计各组SLEDAI积分。结果治疗组治疗后血清PAF含量及SLEDAI积分均明显低于对照组,差异具有显著性意义(P<0.05)。结论清热活血方治疗LN热毒血瘀证,可降低患者血清PAF含量,降低其疾病活动度,是一种较好的治疗方法。

Objective To investigate the effect of Qingre Huoxue decoction on serum PAF level in patients with lupus nephritis（LN） belonged to noxious heat blood stasis syndrome. Methods 42 cases of selected patients were randomly divided into two groups.The treatment group had 22 cases, and the control group had 20 cases. All patients were treated with conventional Western medicine such as glucocorticoid. The treatment group was additionally given Qingre Huoxue decoction for 1 month. Then the level of serum PAF and SLEDAI scores were observed respectively before and after the treatment in two groups. Results The level of serum PAF and SLEDAI scores had decreased obviously in the treatment group more than the control group, and the difference had significant significantce（P〈0.05）. Conclusion Qingre Huoxue decoction could significantly reduce the level of serum PAF and SLEDAI scores in patients with LN belonged to noxious heat blood stasis syndrome, and is a kind of better therapy.