乌司他丁对老年食管癌根治术后患者认知功能的影响分析

The effect of ulinastatin on postoperative cognitive dysfunction of elderly patients with radical esophagectomy

目的探讨食管癌根治术中接受乌司他丁治疗对老年患者术后认知功能的影响。方法以接受食管癌根治术治疗的老年食管癌患者80例作为研究对象,采用随机数字表法将患者分为术中接受乌司他丁治疗的观察组及未接受乌司他丁治疗的对照组,每组各40例。对比分析两组患者接受手术治疗前后认知功能的情况。结果术前两组简易精神状态评价量表(MMSE)评分,术后恢复质量评估量表(PQRS)评分及成人韦氏记忆量表(WMS)记忆商分数比较差异均无统计学意义(P﹥0.05);在术后1 d及术后7 d时,观察组MMSE评分、PQRS评分及WMS记忆商分数均明显高于对照组,两组比较差异均具有统计学意义(P﹤0.01);两组患者术后MMSE评分、PQRS评分及WMS记忆商分数均较术前明显降低,且随着术后时间的延长呈升高趋势,差异均具有统计学意义(P﹤0.01)。结论乌司他丁可有效地改善食管癌患者POCD。

Objective To analyze the impact of ulinastatin treatment on the postoperative cognitive function of elder-ly patients with radical esophagectomy. Method 80 elderly patients who had underwent radical esophagectomy were en-rolled in this study, and were randomized in to study group or control group, according to a random number table, with 40 cases in each, administering intraoperative ulinastatin in study group and no treatment in control group. The cognitive function of the two groups before and after surgery were compared. Result There were no significant differences be-tween the two groups in regard of preoperative Mini-Mental State Examination （MMSE）, Postoperative recovery Quality Assessment Scale （PQRS score） and Adult Wechsler Memory Scale （WMS） memory quotient（P〉0.05）;and the MMSE score, PQRS score and WMS memory quotient in study group at 1-and 7-d after surgery were significantly higher than that of control group （P〈0.01）;at the same time, the postoperative MMSE score, PQRS scores and WMS memory quo-tient were significantly lower after surgery, and tended to increase as the time after surgery elapsed （P〈0.01）. Conclusion Ulinastatin can significantly improve postoperative cognitive function in the elderly patients with esophageal cancer.