摘要
肝细胞癌（HCC）是世界范围内最常见的恶性肿瘤之一。微RNAs（miRNAs）是一类内源性非编码的单链RNAs，在恶性肿瘤的演变过程中发挥癌基因或抑癌基因作用。研究表明miRNAs在HCC的发生发展过程中发挥着重要作用。研究显示，miR-34a在多种肿瘤中表达下调，并参与肿瘤的发生及演变。目前，miR-34a在HCC发生发展中的作用已引起广泛关注。研究证实，miR-34a可通过调控靶基因的表达而影响HCC细胞的增殖、凋亡、侵袭和转移等多个关键生物学过程。本文就miR-34a在HCC中的作用研究进展做一综述。
Primary hepatocellular carcinoma （HCC） is one of the most common malignant tumors worldwide. MicroR- NAs （miRNAs） are a kind of endogenous non coding single- stranded RNAs, which can function as a tumor promoter or sup- pressor in the development and progression of human malignant tumors. Studies have shown that miRNAs play an important role in the occurrence and development of HCC. Numerous studies have found that the expression of miR-34a in various tumors is reduced and it participates in the carcinogenesis. Currently, the role of miR-34a in the tumorigenesis and development of HCC has attracted widespread attentions. Studies have confirmed that miR-34a can regulate the expression of its target genes and thus affect some key biological processes such as cell proliferation, apoptosis, invasion and metastasis of HCC. In this paper, we mainly reviewed the recent research progress on the role of miR-34a in HCC.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2016年第7期496-500,共5页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学青年基金（81302059）
黑龙江省留学归国人员科研基金（LC2013C35）
黑龙江省教育厅面上基金（12541300）
关键词
微RNA
微R-34a
肝细胞癌
细胞增
MicroRNA, miR-34a
Hepatocellularcarcinoma
Cell proliferation
Apoptosis
Invasion
Metastasis
