摘要
肝再生磷酸酶-2(phosphatase of regenerating liver-2,PRL-2)是蛋白酪氨酸磷酸酶家族的成员。作为一种蛋白磷酸酶,PRL家族因其成员PRL-3在肿瘤组织中的特异性高表达而备受人们关注。在近几年的研究中,人们逐渐把目光转向了在正常人体各个组织中均高表达的PRL-2分子,现综述了PRL-2的生物学功能及其在肿瘤相关研究中的最新进展。
Phosphatase of regenerating liver-2 （PRL-2） is a member of protein tyrosine phosphatases family. As a protein phosphatase, PRL-3, the third member of PRL family, has attracted much interest due to its specific high expression in tumor tissues. However, as PRL-2 is widely expressed in normal adult tissues, researchers have become more and more interested in PRL-2. Here, we provide an overview of the physcial function of PRL-2 and its role in cancer.
出处
《生命科学》
CSCD
2016年第7期777-780,共4页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81471971
8117-2808)
上海浦江计划(14PJ1406000)
关键词
肝再生磷酸酶.2
生物学功能
肿瘤
phosphatase of regenerating liver-2
physical function
neoplasm
