HPV不同亚型感染与宫颈病变的关系

Different subtypes of HPV infection and cervical lesions

目的探讨HPV不同亚型感染与宫颈病变的关系。方法对我院经病理组织学证实为宫颈病变513例行HPV分型检测的患者资料进行回顾性分析。结果 576例宫颈病变患者的HPV检测后发现,总阳性率为45.31%;不同年龄段HPV检测阳性率有所差别,其中30-39岁、40-49岁感染率最高,60-64岁感染率最低（P〈0.05）;因患者合并多重感染现象,261例HPV感染的宫颈病变标本中共检测出284次,共计HPV亚型15种。检出的15种HPV亚型中,HPV16和病变程度有关,即随着宫颈病变级别的逐渐提升,检出率也逐渐提升（P〈0.05）。结论宫颈病变主要致病基因型包括HPV16、HPV58、HPV31、HPV18等,特别是HPV16型和宫颈病变程度密切相关,高危型HPV多重感染及持续感染是造成宫颈癌变的主要原因。

Objective To explore the different subtypes of HPV infection and the relationship between cervical lesions.Methods In our hospital confirmed by pathological histology for cervical lesions to analyze the data of 513 routine HPV type detection were retrospectively analyzed.Results Five hunderd and seventy-six cases of cervical lesions in patients with HPV testing and found that total positive rate was 45.31%.Different age groups of patients HPV testing positive rate is different,in which patients aged 30 -39,40 -49,the highest infection rate,the age of 60 -64 patient infection rate is lowest（P〈0.05）.The phenomenon of multiple infections,the merger of patients,261 cases of HPV infection detected 284 specimens of cervical pathological changes of the Chinese communist party,a total of 15 types of HPV subtypes.Check out15 types of HPV subtypes,HPV16 relationship and degree of pathological changes,and with the rising of the cervical lesion level,detection rate also gradually improve（P〈0.05）.Conclusion Cervical lesions main pathogenic genes including HPV16,HPV58,HPV31 and HPV18,especially the group type and the relationship between the degree of cervical lesions,is a major cause of cervical cancer become high-risk type HPV infection and multiple persistent infection.