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Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma 被引量:1

Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma
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摘要 A 16-year-old girl was administered to our hospital because of primary amenorrhea and solid pelvic mass. She was 158 cm tall and weighed 55 kg. There was no evidence ofacanthosis nigricans, acne, hirsutism, goiter, cushingoid features, or Turners stigmata. Examination of secondary sexual characteristics revealed that the breast was small and poorly developed (Tanner's Stage II). Pubic hair was absent while the external genitalia was of female type and had no evidence of clitoromegaly. Ultrasonography of the pelvis showed a solid mass diameter about 9 cm in right adnexal area, a normal uterus with endometrium of 3 ram, and left ovary 1.5 cm x1.0 cm. Her serum hormonal assay revealed a low estradiol level of 0.155 nmol/L (normal range: 0.200-0.790 nmol/L in follicular phase) in the background of elevated luteinizing hormone level of 25.47 U/L (normal range: 2.12-10.89 U/L in follicular phase), follicle-stimulating hormone level of 51.36 U/L (normal range: 3.85-8.78 U/L in follicular phase), and testosterone level of 3.97 nmol/L (normal range: 0.35-2.60 nmol/L). She was found to have normal progesterone level of 3.77 nmol/L (0.98-4.83 nmol/L in follicular phase) and serum prolactin level of 12.47 ng/ml (3.34-26.72 ng/ml). A 16-year-old girl was administered to our hospital because of primary amenorrhea and solid pelvic mass. She was 158 cm tall and weighed 55 kg. There was no evidence ofacanthosis nigricans, acne, hirsutism, goiter, cushingoid features, or Turners stigmata. Examination of secondary sexual characteristics revealed that the breast was small and poorly developed (Tanner's Stage II). Pubic hair was absent while the external genitalia was of female type and had no evidence of clitoromegaly. Ultrasonography of the pelvis showed a solid mass diameter about 9 cm in right adnexal area, a normal uterus with endometrium of 3 ram, and left ovary 1.5 cm x1.0 cm. Her serum hormonal assay revealed a low estradiol level of 0.155 nmol/L (normal range: 0.200-0.790 nmol/L in follicular phase) in the background of elevated luteinizing hormone level of 25.47 U/L (normal range: 2.12-10.89 U/L in follicular phase), follicle-stimulating hormone level of 51.36 U/L (normal range: 3.85-8.78 U/L in follicular phase), and testosterone level of 3.97 nmol/L (normal range: 0.35-2.60 nmol/L). She was found to have normal progesterone level of 3.77 nmol/L (0.98-4.83 nmol/L in follicular phase) and serum prolactin level of 12.47 ng/ml (3.34-26.72 ng/ml).
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第14期1752-1754,共3页 中华医学杂志(英文版)
关键词 GONADOBLASTOMA Ovarian Germ Cell Tumors Swyer's Syndrome Gonadoblastoma Ovarian Germ Cell Tumors Swyer's Syndrome
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  • 1Culha C, Ozkaya M, Setter R, Sahin I, Aydin B, Aral Y. Swyer's Syndrome: In a fifty-year-old female. J Obstet Gynaecol India 2012;62:571-4. doi: 10.1007/s13224-011-0100-1.
  • 2Marchina E, Gambera A, Spinelli E, Clerici P, Scagliola P, Sartori E, et al. Identification of a new mutation in the SRY gene in a 46,XY woman with Swyer syndrome. Fertil Steril 2009;91:932.e7-11. doi: 10.1016/j.fertnstert.
  • 3Aggarwal P, Kehoe S. Serum tumour markers in gynaecological cancers. Maturitas 2010;67:46-53. doi: 10.1016/j.maturitas.2010.04.017.
  • 4NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Ovarian Cancer. Available from: http://www.nccn. org/professionals/physician_gls/f_guidelines.asp#ovarian. [Last accessed on 2016 Mar 21].
  • 5Morsy AH, al-Fadly A, Mokhtar S, el-Aasar EM, Farag TI. Swyer syndrome: An unusual presentation. Int J Gynaecol Obstet 1995;49:185-6. doi: 10.1016/0020-7292(94)02334-U.

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