原发性肝癌血清AFP、AFP-L3表达与CT影像的关系

Analysis of relationship between serum AFP,AFP-L3 expression levels and CT images in primary hepatic carcinoma patients

目的探讨原发性肝癌患者血清甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)与CT征象的相关性。方法选择2012年2月至2015年3月本院收治的64例原发性肝癌患者作为研究对象,均经手术切除且病理证实,另外选取医院同期确诊的肝硬化患者60例,患者均行多层CT常规与增强扫描,ELISA法测定血清AFP、AFPL3,分析CT扫描联合AFP、AFP-L3在原发性肝癌诊断中价值,AFP、AFP-L3表达水平与CT征象的相关性。结果AFP、AFP-L3阳性表达在包膜不完整情况下明显高于包膜完整情况(P<0.05);肿瘤临床分期越晚AFP、AFPL3阳性表达率越高(P<0.05),肝细胞癌中AFP、AFP-L3阳性表达率高于胆管细胞癌(P<0.05),有转移患者AFP、AFP-L3阳性表达率高于非转移者(P<0.05)。结论检测血清AFP、AFP-L3联合CT扫描在诊断原发性肝癌方面有重要意义,血清AFP、AFP-L3表达与原发性肝癌CT影像中肿瘤大小及包膜情况、肿瘤临床分期、病理类型、转移有一定相关性。

Objective This paper was to investigate the relationship between serum AFP,AFP-L3 expression levels and CT images in primary hepatic carcinoma patients.Methods A total of 64 patients with primary liver cancer from February 2012 to March 2015 in hospital were selected,and they were confirmed by surgery and pathology.A total of 60 patients with cirrhosis in the same period were selected.The patients were underwent multisided CT conventional and enhanced scan,serum AFP,AFP-L3 was detected by ELISA assay,the value of CT scans combined with AFP,AFP-L3 in the diagnosis of primary liver cancer was analyzed.The relationship between serum AFP,AFP-L3 expression levels and CT images were analyzed.Results The positive expression of AFP-L3 and AFP was significantly higher than that in the whole envelope（P0.05）.The positive expression rates of AFP,AFP-L3 in later clinical stage were higher than the early stage（P0.05）,hepatocellular carcinoma were higher than in cholangiocarcinoma（P0.05）,and the distant metastasis in patients were higher than the non-distant metastasis（P0.05）.Conclusion The results show that the detection of AFP,AFP-L3 combined with CT features has important value in the diagnosis of primary hepatic cancer.The serum AFP,AFP-L3 expression has certain relevance to CT imaging of primary tumor size and capsule,clinical staging,histological type and distant metastasis.