妊娠期不同时段鼾症与子痫前期发病的相关性研究

Association of snoring in pregnancy with preeclampsia

目的探讨妊娠期不同时段鼾症的发生情况及其与子痫前期发病的关系。方法对2015年3月至2015年8月北京大学人民医院产前检查并住院分娩的462例妇女进行问卷调查,随访母体结局,比较鼾症组和非鼾症组子痫前期发病的差异;多因素logistic回归分析子痫前期发病的危险因素。结果 1妊娠前、早、中、晚期鼾症的发病率分别为5.41%（25/462）、5.63%（26/462）、20.13%（93/462）和24.46%（113/349）,各阶段发病率比较,差异有统计学意义（P〈0.05）。2在妊娠各时段,鼾症组子痫前期的发病率均显著高于非鼾症组（P〈0.05）。3多因素回归分析显示,年龄（≥35岁）、孕前BMI（≥30 kg/m2）及妊娠中期打鼾是子痫前期发病的独立危险因素,比值比（OR）分别为1.30（95%CI：1.13~1.49,P=0.000）、1.26（95%CI：1.11~1.44,P=0.001）和4.95（95%CI：1.80~13.65,P=0.002）。结论随着妊娠的进展,鼾症的发生呈上升趋势;鼾症组子痫前期的发病率显著升高;妊娠中期鼾症是子痫前期发病的独立危险因素,应重视鼾症孕妇的围生期保健。

Objective To explore the association of snoring in pregnancy with preeclampsia. Methods Pregnant women（n = 462） receiving prenatal care provided information about habitual snoring before and during pregnancy in inperson interviews completed in late pregnancy. We calculated the incidence of snoring at different stage of pregnancy, compare the association of snoring with preeclampsia, multilogistic analysis of factors associated with preeclampsia. Results Snoring was significantly observed to be increased in pregnancy,the incidence was 5.41%, 5.63%, 20.13%, 24.46% at prepregnancy,1st, 2nd and 3rd trimester respectively（P 〈0.05）. The occurrence of preeclampsia was higher in snorers compared with that in nonsnorers（P 〈 0.05） in pregnancy. Advanced maternal age（≥35 years）（OR = 1.30, 95 % CI： 1.13~1.49, P=0.000）, prepregnancy obesity（BMI≥30 kg/m2）（OR=1.26, 95 % CI： 1.11~1.44, P=0.001） and snoring at 2nd trimester（OR=4.95, 95%CI： 1.80~13.65, P=0.002）were statistically significant risk factors for preeclampsia. Conclusions Snoring is common and the incidence increased with the progress of pregnancy. Snoring indicates a high risk of preeclampsia, so attention should be paid to pregnant women with snoring.