钱英教授辨治原发性肝癌的经验探析

Syndrome differentiation-based treatment of primary liver cancer developed by Professor Qian Ying: an analysis of experience

目的分析钱英教授辨治原发性肝癌的常用药物及核心处方,以指导临床用药。方法回顾性分析钱英教授诊治的原发性肝癌患者的临床资料,采用描述性分析法对钱英教授治疗原发性肝癌的临床用药与方剂进行分析,使用复杂网络与点式互信息法聚类技术分析多味药之间复杂的关联性。结果纳入111例原发性肝癌患者,共287张处方,总计应用132味中药治疗。钱英教授治疗的核心药物为槲寄生、生黄芪、丹参、白花蛇舌草、水红花子等,此结果与其创制的槲芪散方药组成有较好的一致性。常用方剂为槲芪散、生脉饮、逍遥散等方剂。结论钱英教授治疗原发性肝癌的特色药物为槲寄生,常用方药为其创制的槲芪散。

Objective To investigate the traditional Chinese herbs and core prescriptions commonly used by Professor Qian Ying in the syndrome differentiation- based treatment of primary liver cancer,and to guide clinical medication. Methods A retrospective analysis was performed for the clinical data of the patients diagnosed and treated by Professor Qian Ying. A descriptive analysis was performed to analyze Professor Qian Ying＇s clinical medication and prescriptions in the treatment of primary liver cancer,and the complex network and clustering with point mutual information were used to analyze the complex association between multiple traditional Chinese herbs. Results A total of111 patients with primary liver cancer were enrolled. There were 287 visits,287 prescriptions,and 132 traditional Chinese herbs in total.The core herbs used by Professor Qian Ying were Visci herba,raw Astragalus membranaceus,Salvia miltiorrhiza,Oldenlandia diffusa,and Polygoni Orientalis Fructus,and this result was consistent with the composition of Huqi powder developed by Professor Qian Ying. The prescriptions commonly used included Huqi powder,Shengmai decoction,and Xiaoyao powder. Conclusion Salvia miltiorrhiza is the special herb used by Professor Qian Ying in the treatment of primary liver cancer and Huqi powder developed by Professor Qian Ying is the commonly used prescription.