搜风通胶囊联合单硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛随机平行对照研究

Soufeng Capsule combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease Angina Pectoris Randomized Controlled Study

[目的]观察搜风通胶囊联合单硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛疗效。[方法]使用随机平行对照方法,将75例住院患者按病志号抽签方法简单随机分为两组。对照组35例单硝酸异山梨酯40mg/次,1次/d,口服;急性发作速效救心丸,4~6丸/次,口服,吸氧。治疗组35例搜风通胶囊4粒/次,3次/d,口服;西药治疗同对照组。连续治疗1个月为1疗程。观测临床症状、心绞痛发作、全血黏度、血浆黏度、红细胞比容、纤维蛋白原、血小板、心电图、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效12例,有效20例,无效3例,总有效率91.43%。对照组显效10例,有效15例,无效10例,总有效率71.43%。治疗组疗效优于对照组（P〈0.05）。低切WBV、HCT、FIB两组均有改善（P〈0.05）,低切WBV、FIB治疗组改善优于对照组（P〈0.05,P〈0.01）,HCT改善两组无明显差异（P〉0.05）;高切WBV、PV治疗组明显改善（P〈0.05）,对照组无明显变化（P〉0.05）,治疗组改善优于对照组（P〈0.01,P〈0.05）;FIB两组均有改善（P〈0.01,P〈0.05）,两组无明显差异（P〉0.05）;BPC两组均无明显变化（P〉0.05）。[结论]搜风通胶囊联合单硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛,疗效满意,无严重不良反应,优于单纯单硝酸异山梨酯治疗,值得推广。

[Objective] To observe soufeng capsule combined with isosorbide mononitrate in the treatment of coronary heart disease angina pectoris. [Method] Using random parallel control method, 75 cases of hospitalized patients according to disease will draw simple method, were randomly divided into two groups. The control group of 35 cases of isosorbide mononitrate 40 rag/times, 1 times/d, oral; acute attack of available Kyushin Pills, 4-6 pills/time, oral, inhalation. The treatment group of 35 cases of soufeng capsule 4 pills/time, 3 times/d, oral administration of western medicine with the control group. Continuous treatment for 1 months for the 1 course of treatment. Observation of clinical symptoms, angina pectoris attacks, whole blood viscosity, plasma viscosity, red cell specific volume, fibrin fibrinogen and platelet, electrocardiogram, adverse reactions. Treatment of 1 courses of treatment, determine efficacy. [Results] In the treatment group, 12 cases were markedly effective, 20 cases were effective, 3 cases were ineffective, the total effective rate was 91.43%. The control group was 10 cases, 15 cases were effective, 10 cases ineffective, the total efficiency of 71.43%. The treatment group than the control group （P 〈0.05）. Two groups of two groups of low cut WBV, HCT, FIB in both groups were improved （P〈0.05） low shear WBV and Fib in the treatment group is better than control group （P〈0.05, P〈0.01） and HCT improvement of two groups had no significant difference （P〉0.05）; high shear WBV, PV treatment group improved significantly （P〈0.05）, the control group had no significant change （P〉0.05）, the treatment group is better than control group （P〈0.01, P〈0.05）; FIB were improved （P〈0.01, P〈0.05）. The two groups had no significant difference （P 〉0.05）; BPC showed no significant change （P〉0.05）. [Conclusion] Soufeng capsule combined with isosorbide mononitrate in the treatment of coronary heart disease angina pectoris, satisfactory curative effect, no serious adverse reaction, better than isosorbide mononitrate treatment, worthy of promotion.