帕罗西汀联合针刺治疗难治性强迫症的对照研究

Paroxetine combined with acupuncture in treatment of refractory obsessive-compulsive disorder

目的探讨针刺治疗难治性强迫症患者的临床效果和安全性。方法将60例难治性强迫症患者随机分为研究组（帕罗西汀＋针刺，n=30）和对照组（帕罗西汀，n=30）进行治疗，疗程为8周。采用耶鲁一布朗强迫症状评定量表（Y—BOCS）、汉密尔顿抑郁量表（HAMD）评价两组疗效；采用副作用量表（TESS）评价两组安全性。结果研究组和对照组有效率分别为80．0％和66．7％，差异有统计学意义（P〈0．05）；治疗后，研究组Y—BOCS、HAMD评分下降更明显（P〈0．01）；两组在治疗过程中出现的副作用比较，差异无统计学意义（P〉0．05）。结论针刺合并帕罗西汀治疗难治性强迫症可提高疗效，且安全忡好．佰得讲一彤椎广府用．

Objective To explore the efficacy and safety of acupuncture in the treatment of refractory obsessive-compulsive disorder （ROCD）. Methods 60 patients with ROCD were randomly divided into a study group （n=30, acupuncture combined with paroxetine 40-60 mg/d） and a control group （n=30, paroxetine 40-60 mg/d）. Both groups were treated for 8 weeks. The efficacy was assessed with Yale-Brown obsessive-compulsive scale（Y-BOCS） and Hamilton depression scale（HAMD）. The side effects were assessed with treatment emergent symptom scale（TESS）. Results The overall effective rate was significantly higher in the study groupthan in the control group （80.0% vs. 66.7%, P〈0.05）. The scores of YBOCS and HAMD decreased more in the study group than in the control group （P〈0.01）. There were no statistical differences in TESS between the study group and the control group （/：＇〉0.05）. Conclusions Acupuncture combined with paroxetine for patients with ROCD is effective and safe.