断奶应激对幼龄反刍动物免疫系统的影响及其机理

Effects and Mechanism of Weaning Stress on Immune System in Young Ruminants

断奶初期,幼龄反刍动物的消化和免疫系统等尚未发育完全,断奶应激会导致幼畜体内激素水平及免疫功能改变,引起免疫系统抑制,诱发炎症反应,阻碍幼畜生长发育,增加患病风险。本文从糖皮质激素、免疫细胞、急性期蛋白和相关细胞因子4个方面阐述了断奶应激对幼龄反刍动物免疫系统的影响及其机理,旨在为相关研究提供科学依据。

The digestive and immune systems have not yet developed completely,when young ruminants were weaned. W eaning stress leaded to adolescent alterations in hormone levels and immune function,which could suppress immune system and cause inflammatory response,consequently restricted their growth and increased the risk of disease in ruminants. In this article,the effects and mechanism of weaning stress on the immune system in young ruminants were discussed,focusing on glucocorticoid,immune cell,acute phase proteins and related cytokine,with the aim of providing a scientific basis for the relevant research.