还原型谷胱甘肽联合自拟降脂方对酒精性脂肪肝患者血清酶及脂质过氧化水平的影响

Effects of Reduced Glutathione Combined with Self-designed Lipid-lowering Decoction on Serum Enzyme and Lipid Peroxide Levels of Patients with Alcoholic Fatty Liver

目的探讨还原型谷胱甘肽联合自拟降脂方对酒精性脂肪肝患者血清酶及脂质过氧化指标的影响。方法选择2014年2月—2015年10月就诊的酒精性脂肪肝92例,根据治疗方法分为观察组52例和对照组40例。对照组给予还原型谷胱甘肽治疗,观察组在对照组基础上联合自拟降脂方治疗。观察两组临床疗效、不良反应、治疗前后血脂、血清酶及脂质过氧化指标变化情况。结果观察组治疗总有效率高于对照组(P<0.05)。两组治疗后总胆固醇(TC)、甘油三酯(TG)、血清丙氨酸转氨酶、γ-谷氨酰转肽酶、天冬氨酸转氨酶、丙二醛水平较治疗前下降,高密度脂蛋白胆固醇、超氧化物歧化酶较治疗前升高,且观察组治疗后上述指标改善情况优于对照组(P<0.05)。两组均未发生明显不良反应。结论还原型谷胱甘肽联合自拟降脂方能明显降低酒精性脂肪肝患者TG、TC及血清酶指标,有效改善患者肝功能,其作用机制可能为抑制肝脏脂质过氧化反应。

Objective To investigate effects of Reduced Glutathione combined with self-designed lipid-lowering decoction on levels of serum enzyme and lipid peroxidation indexes of patients with alcoholic fatty liver. Methods A to-tal of 92 patients with alcoholic fatty liver admitted during February 2014 and October 2015 were divided into observation group （n=52） and control group （n=40） according to therapic methods. control group was treated with Reduced Gluta-thione, while observation group was treated with self-designed lipid-lowering decoction based on Reduced Glutathione treatment. Clinical curative effects, adverse reactions, changes of blood lipid, serum enzyme and lipid peroxidation inde-xes before and after treatment were observed in two groups. Results Total effective rate in observation group was higher than that in control group （P〈0. 05）. After treatment, levels of total cholesterol （TC）, triglyceride （TG）, serum ala-nine transaminase, γ-glutamyl transpeptidase, aspartate transaminase and malondialdehyde were lower, while levels of high density lipoprotein cholesterol and superoxide dismutase were higher than those before treatment in two groups, and improvement of the above indexes in observation group was better than those in control group after treatment （P〈0. 05）. There were no obvious adverse reactions in two groups. Conclusion Reduced Glutathione combined with self-designed lipid-lowering decoction can significantly reduce TG, TC and serum enzyme indexes and effectively improve liver function of patients with alcoholic fatty liver. Its mechanism of action is perhaps that of inhibiting hepatic lipid peroxidation.