复方丹参对早发型重度子痫前期患者妊娠结局及新生儿的影响

Effects of Compound Danshen on Pregnancy Outcome of Patients with Early Onset of Severe Preeclampsia and Newborns

目的观察复方丹参对早发型重度子痫前期患者妊娠结局、新生儿甲状腺激素水平的影响及并发症发生情况。方法对2012年2月—2015年10月收治的96例早发型重度子痫前期患者的临床资料进行回顾性分析,根据治疗方案分为复方丹参组50例与常规治疗组46例。常规治疗组采取期待治疗,复方丹参组在期待治疗基础上应用复方丹参注射液。观察两组妊娠结局、产妇及新生儿并发症发生情况和新生儿甲状腺激素水平。结果两组产后2 h出血量、新生儿体重、产妇胎盘早剥、肾衰竭、低血小板综合征、心功能不全、肝功能损害发生率比较差异无统计学意义(P>0.05)。复方丹参组终止妊娠孕周长于常规治疗组,新生儿促甲状腺激素、总三碘甲腺原氨酸、总甲状腺素、游离三碘甲腺原氨酸、游离甲状腺素高于常规治疗组,生长受限、胎儿窘迫、新生儿窒息、胎死宫内、新生儿死亡发生率低于常规治疗组(P<0.05)。结论复方丹参治疗早发型重度子痫前期患者可延长孕周,利于新生儿甲状腺发育,且安全性较高。

Objective To observe effects of Compound Danshen on pregnancy outcome of patients with early on-set of severe preeclampsia and levels of thyroid hormones of newborns and to analyze incidence rate of complications. Methods Clinical data of 96 patients with early onset of severe preeclampsia admitted during February 2012 and October 2015 was retrospectively analyzed, and the patients were divided into Compound Danshen group （ n=50 ） and routine treatment group （ n=46 ） according to therapic methods. Routine treatment group received expectant treatment, while Compound Danshen group was treated with Compound Danshen Injection based on expectant treatment. Pregnancy out-come , incidence rate of complications of puerpera and newborns and levels of thyroid hormones of newborns were observed in two groups. Results There were no significant differences in postpartum 2h bleeding volume, neonatal birth weight, placental abruption of puerpera, incidence rates of renal failure, hemolytic anemia, elevated liver function and low plate-let count syndrome （HELLP syndrome）, cardiac dysfunction and liver function damage between two groups （P〉0. 05）. Compared with those in routine treatment group, in Compound Danshen group, gestational weeks of pregnancy termination was longer;levels of neonatal thyroid stimulating hormone, total triiodothyronine, total thyroxine, free triiodothyronine and free thyroxine were higher;incidence rates of growth restriction, fetal distress, neonatal asphyxia, dead fetus in ute-rus and neonatal death were lower （P〈0. 05）. Conclusion Compound Danshen Injection in treatment of patients with early onset of severe preeclampsia can prolong gestational weeks, and it is conductive to neonatal thyroid gland develop-ment with good safety.