青海省藏族与汉族肺结核患者抗结核药物血药浓度的比较

Comparison of blood concentration of anti-tuberculosis drugs in Tibetan and Han patients with pulmonary tuberculosis in Qinghai province

目的测定青海省藏、汉族肺结核患者血浆中抗结核药物的稳态浓度并进行比较，为临床合理应用抗结核药物提供理论依据。方法选取2013年12月至2014年5月青海大学附属医院及青海省第四人民医院确诊的肺结核患者114例，其中藏族患者69例，汉族患者45例。用高效液相色谱法测定所有患者用药第7天清晨空腹口服抗结核药物后2h血浆中异烟肼、利福平、吡嗪酰胺的稳态血药浓度并进行比较。结果藏、汉族肺结核患者血浆中异烟肼、利福平、吡嗪酰胺血药浓度[（13．9±7．7）μg/L比（10．7±5．2）μg/L、（2．0±1．9）mg／L比（2．3±1．9）mg/L、（5973±3281）μg／L比（6452±3563）μg／L]差异均无统计学意义（P〉0．05）。结论藏族肺结核患者在抗结核治疗时可与汉族患者应用同等剂量的抗结核药物。

Objective To detect and compare blood concentrations of anti-tuberculosis drugs in Tibetan and Han patients with pulmonary tuberculosis, to provide the theory evidence for clinical rational drug use. Methods Totally 114 cases of pulmonary tuberculosis from December 2013 to May 2014 in Qinghai University Affiliated Hospital and the 4th People＇s Hospital of Qinghai Province were enrolled, including 69 cases of Tibetan patients and 45 cases of Han patients. At the 7th day of anti-tuberculosis drug use, the high performance liquid chromatography was used to detect blood concentrations of isoniazid, rifampicin and pyrazinamide. Results There were no significant differences of blood concentrations of isoniazid, rifamipicin and pyrazinamide between groups （13.9 ±7.7） μg/L vs （10.7±5.2）μg/L,（2.0± 1.9） mg/L vs （2.3±1.9）mg/L, （5 973 ±3 281）μg/L vs （6 452 ± 3 563 ） μg/L ] （ P 〉 0.05 ）. Conclusion Same doses of anti-tuberculosis drugs can be used in both Tibetan patients and Han patients.