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电针缓解绝经过渡期相关症状的临床研究 被引量:5

Clinical Study on Electroacupuncture in Mitigating the Symptoms Related to Menopausal Transition
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摘要 目的观察对比电针及安慰电针对绝经过渡期相关症状的调节作用及二者对血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)的影响,评价电针缓解绝经过渡期相关症状的临床有效性。方法将符合纳入标准的30例绝经过渡期患者随机分为治疗组和对照组,每组15例。治疗组给予经穴电针治疗,对照组给予经穴旁非穴点安慰电针治疗。检测两组治疗后及随访第20星期时E2、FSH及LH水平,观察两组治疗4、8星期后及随访第20、32星期时烘热积分、绝经症状评价量表(MRS量表)评分的变化情况,并对电针治疗进行安全性评价。结果两组治疗4、8星期后及随访第20、32星期时MRS评分和烘热积分均较同组治疗前显著下降(P<0.01,P<0.05)。两组治疗8星期后与治疗前MRS评分差值比较,差异具有统计学意义(P<0.01)。两组治疗8星期后及随访第20、32星期与治疗前烘热积分差值比较,差异均具有统计学意义(P<0.01)。治疗组治疗8星期后血清E2、FSH、LH水平与同组治疗前比较,差异均具有统计学意义(P<0.05)。两组治疗8星期后与治疗前FSH、LH水平差值比较,差异均具有统计学意义(P<0.05)。两组随访第20星期与治疗前血清E2水平差值比较,差异具有统计学意义(P<0.05)。结论电针治疗能改善绝经过渡期患者的烘热症状,并对其激素水平起到良性调节作用,但该调节作用无明显治疗后效应。 Objective To observe and compare the regulating effect between electroacupuncture and sham electroacupuncture on the symptoms of menopausal transition and levels of estradiol(E2), follicle-stimulating hormone(FSH), and luteinizing hormone(LH), for evaluating the clinical efficacy of electroacupuncture in mitigating the relevant symptoms of menopausal transition. Method Thirty eligible subjects with menopausal transition were randomized into a treatment group and a control group, 15 cases in each group. The treatment group was intervened by electroacupuncture at the ordinary acupoints, while the control group was by electroacupuncture at non-meridian points. The E2, FSH, and LH contents were detected after intervention and at the 20 th week during the follow-up study, the flush score and Menopause Rating Scale(MRS) were evaluated respectively after 4-week and 8-week treatment and at the 20 th week and 32 nd week during the follow-up study, and the safety of electroacupuncture was also estimated. Result The flush and MRS scores were significantly changed after 4-week and 8-week treatment and at the 20 th week and 32 nd week during the follow-up study in both groups compared to that before the treatment in the same group(P〈0.01,P〈0.05). There was a significant difference in comparing the changes of MRS score after 8-week treatment between the two groups(P〈0.01). There were significant differences in comparing the changes of flushing scores between the two groups after 8-week treatment and at the 20 th week and 32 nd week during the follow-up study(P〈0.01). The serum levels of E2, FSH, and LH were significantly changed in the treatment group after 8-week treatment(P〈0.05). There were significant differences in comparing the changes of FSH and LH levels between the two groups after 8-week treatment(P〈0.05). The difference in comparing the change of serum E2 level between the two groups at the 20 th week during the follow-up study was statistically significant(P〈0.05). Conclusion Electroacupuncture can improve the flushing intensity and produce a benign regulation on the relevant hormone levels in menopausal transition, though this regulation is insignificant when the treatment terminates.
出处 《上海针灸杂志》 2016年第7期839-843,共5页 Shanghai Journal of Acupuncture and Moxibustion
基金 "十二五"国家科技支撑计划(2012BAI24B01)
关键词 针刺疗法 电针 绝经过渡期 雌二醇 卵泡刺激素 黄体生成素 更年期综合征 Acupuncture therapy Electroacupuncture Menopausal transition Estradiol(E2) Follicle-stimulating hormone(FSH) Luteinizing hormone(LH) Perimenopausal syndrome
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