阿魏酸钠联合坎地沙坦对早期糖尿病肾病尿微量白蛋白水平的影响

Effect of sodium ferulate combined with candesartan on urine microalbumin levels in patients with early diabetic kidney disease

目的分析阿魏酸钠联合坎地沙坦对早期糖尿病肾病患者尿微量白蛋白水平的影响,探讨联合治疗对糖尿病肾脏的保护作用。方法选择在我院住院治疗的早期糖尿病肾病患者180例,在常规治疗基础上随机分为2组:对照组予以坎地沙坦治疗,观察组予以阿魏酸钠联合坎地沙坦治疗。比较两组患者治疗前后尿微量白蛋白/尿肌酐(ACR)水平以及其他肾脏功能相关指标,并比较两组患者ACR、血肌酐水平(Cr)、血清胱抑素C水平(CysC)、肾小球滤过率(eGFR)以及24 h尿蛋白(24 h UP)的变化率(ΔACR、ΔCr、ΔCysC、ΔeGFR、Δ24 h UP)。结果治疗后,与对照组比较,观察组ACR、Cr、24 h UP显著降低(P<0.05),eGFR显著升高(P<0.05);观察组ΔACR、ΔCr、ΔeGFR以及Δ24 h UP显著高于对照组(P<0.05)。结论阿魏酸钠联合坎地沙坦显著降低尿微量白蛋白水平,对糖尿病肾病的治疗效果优于单用坎地沙坦。

Objective To analyze the effect of sodium ferulate combined with candesartan on twine microalbu- min levels in patients with early diabetic kidney disease （DKD）. Methods Totally 180 patients with early DKD were selected and randomly divided into control group （ n = 90） and observation group （ n = 90 ）. Control group was treated with candesartan, and observation group was treated with sodium ferulate combined with candesartan. Urinary mi- croalbumin/creatinine ratio （ACR） levels and other renal-function-related indicators of the two groups before and after treatment were compared. ACR, Cr, CysC, eGFR and 24 h UP were measured and AACR, ACr, ACyC, AeGFR and A24 h UP were calculated. Results After treatment, ACR, Cr and 24 h UP of observotion group were significantly lower than those of control group, but eGFR was significantly higher （ P 〈 0. 05 ）. AACR, ACr, AeGFR and A24 h UP were significantly higher in observation group than those of control group （ P 〈 0.05 ）. Conclusion Sodium ferulate combined with candesartan can reduce the level of urinary microalbumin with better efficacy than candesartan alone in the treatment of diabetic kidney disease.