钠通道阻滞剂用于原发性三叉神经痛治疗的疗效观察

Comparison of the effects of Oxcarbazepine and Carbamazepine in the treatment of primary trigeminal neuralgia

目的奥卡西平与卡马西平用于原发性三叉神经痛治疗的效果比较。方法选取原发性三叉神经痛患者213例,随机分为奥卡西平组107例和卡马西平组106例。奥卡西平组予奥卡西平治疗,卡马西平组予卡马西平治疗。观察比较2组临床治疗效果和不良反应发生情况。结果奥卡西平组总有效率为96.26%,高于卡马西平组的78.30%(P<0.05);奥卡西平组不良反应发生率为2.79%,低于卡马西平组的20.75%(P<0.05)。结论奥卡西平用于原发性三叉神经痛治疗,临床效果较卡马西平显著,且不良反应更小,值得临床推广应用。

Objective Compare effects of the Oxcarbazepine and Carbamazepine in the treatment of primary trigeminal neuralgia. Methods Selection of primary trigeminal neuralgia patients 213 cases,randomly divided into oxcarbazepine group（ 107 cases） and carbamazepine group（ 106 cases）. Oxcarbazepine group received oxcarbazepine treatment,carbamazepine group received carbamazepine treatment. The treatment effect and adverse reaction were observed and compared between the 2 groups. Results Oxcarbazepine group total effective rate（ 96. 26%） was higher than the carbamazepine group（ 78. 30%）（ P〈0. 05）; The incidence of adverse reaction of oxcarbazepine group（ 2. 79%） was higher than that of the carbamazepine group（ 20. 75%）（ P〈0. 05）. Conclusion The clinical effect of oxcarbazepine in the treatment of primary trigeminal neuralgia is better than carbamazepine,and less adverse reactions. Worthy of clinical popularization and application.