血清3项肿瘤标志物联合检测对原发性肝癌的诊断意义分析

Analysis of Diagnostic Value of Detecting Primary Liver Cancer by Three Markers in Serum

目的：探讨血清3项标志物联合检测对于原发性肝癌的诊断价值。方法：选取2012年1月~2015年5月在某院就诊的原发性肝癌患者88例为肝癌组,肝硬化患者36例为肝硬化组,及同期在某院健康体检的36例受试者为对照组,3组患者在基本资料比较中显示差异不具有统计学意义,具有临床可比性。对3组患者进行空腹采血,测定血清中AFP、CA199、CA125含量。结果：对3组患者血清中的AFP、CA199、CA125检测结果表明,原发性肝癌患者血清中的三者浓度为（843.21±731.32）、（121.45±231.43）、（207.32±366.11）显著高于肝硬化组和对照组血清中的含量（P〈0.05）,显示差异具有显著统计学意义。对3种肿瘤标志物检测灵敏度等的判断结果显示,敏感度最高的是AFP为83.79%,最低的是CA125为62.53%,联合三者诊断的敏感度为99.24%,特异性较低,仅为53.24%。结论：联合3种肿瘤标志物的测定可以对于原发性肝癌的早期诊断提供依据,具有较高的准确定,临床可以推广使用。

Objective：To study the diagnostic value of detecting primary liver cancer by three markers in serum.Methods：From January 2012 to May 2015 in our hospital 88 cases of primary liver cancer patients as liver cancer group,the group of 36 patients with cirrhosis as the liver cirrhosis group,and at the same time in the hospital 36 subjects receiving physical examination as the control group.The basic information of the three groups are of no statistically significant difference,with clinical comparability.To sample blood of the three groups and determine AFP,CA199,CA125 levels in serum.Results：AFP,CA199,CA125 in the serum of the three groups showed that the three concentrations in the serum of patients with primary liver cancer were（843.21±731.32）,（121.45±231.43）,（207.32±366.11）which were significantly higher than those in cirrhosis group and the control group（P 0.05）,with significantly statistical difference.Judgment on three tumor markers detection sensitivity,the highest sensitivity was AFP 83.79%,the lowest was CA12562.53%,the joint 3diagnostic sensitivity 99.24%,specificity is low,just 53.24%.Conclusion：The combined determination of three tumor markers can provide a basis for the early diagnosis of primary liver cancer,with high certainty,which can be promoted in clinical use.