术中快速冰冻切片检查诊断甲状腺结节的临床观察

Clinical Observation of Intraoperative Frozen Section Examination in Diagnosis of Thyroid Nodules

目的：讨论术中快速冰冻切片检查诊断甲状腺结节的临床价值,为日后的临床诊断提供参考。方法：选择2012年3月~2015年2月收治的甲状腺结节患者112例为研究对象,临床应用抽签的方法,将112例患者划分为两组,分别取名为观察组及对照组,每组患者56例。对照组患者给予常规诊断,观察组患者给予手术治疗,术中进行快速冰冻切片予以明确诊断。结果：甲状腺乳头状癌11例,结节性甲状腺肿大52例,甲状腺腺瘤48例,亚急性淋巴细胞性甲状腺炎1例。观察组患者临床诊断准确率为98.2%,对照组患者临床诊断准确率为73.2%,观察组优于对照组,两组患者比较差异显著,P〈0.05。结论：手术后常规石蜡切片与术中冰冻病理切片诊断一致,无误诊漏诊。术中快速冰冻病理检查诊断率高,对指导手术范围有积极意义,可作为常规检查。建议在今后的甲状腺结节诊断中,应用术中快速冰冻切片检查。

Objective：To discuss the clinical value of intraoperative frozen section examination in the diagnosis of thyroid nodules,and to provide reference for clinical diagnosis.Methods：112patients with thyroid nodules were selected from March 2012 to February,112 patients were divided into two groups,the observation group and the control group,56 cases in each group.The control group was given routine diagnosis,the observation group was given surgical treatment,intraoperative rapid frozen section to be a clear diagnosis.Results：11cases of thyroid papillary carcinoma,52 cases of nodular goiter,48 cases of thyroid adenoma,subacute lymphocytic thyroiditis in 1case.The clinical diagnostic accuracy rate of the observation group was98.2%,the accuracy rate was 73.2%in the control group,the observation group was better than the control group,the difference between the two groups was significant,P0.05.Conclusion：The routine paraffin sections and frozen sections were in agreement with the intraoperative frozen pathological section,and there was no misdiagnosis and missed diagnosis.The fast frozen pathological examination in the operation is high,and it can be used as a routine examination.After surgery,patients recovered well.In the diagnosis of thyroid nodules in the future,rapid frozen section examination is used in the application.