丁苯酞治疗血管性痴呆患者的疗效及对其血清超氧化物歧化酶活性和丙二醛含量的影响

Efficacy of NBP in treatment of vascular dementia and its effects on serum superoxide dismutase activity and malondialdehyde content

目的:观察丁苯酞治疗轻中度血管性痴呆患者的临床疗效及对其血清超氧化物歧化酶活性和丙二醛含量的影响。方法:将60例轻中度血管性痴呆患者随机分为治疗组和对照组,每组各30例。治疗组患者给予丁苯酞治疗;对照组患者给予吡拉西坦治疗。两组患者均给药8周。采用简易精神状态检查(MMSE)、日常生活能力量表(ADL)和临床痴呆程度量表(CDR)评估两组患者的临床效果;检测治疗前后两组患者的血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量。结果:治疗后,治疗组患者的MMSE、ADL评分较治疗前有显著增高,差异有显著性意义(P<0.05);SOD和MDA与治疗前比较(P>0.05),差异无统计学性意义。结论:丁苯酞可有效改善血管性痴呆患者的临床疗效,提高患者生存质量。

Objective： To investigate clinical effects of n-Butylphthalide（ NBP） in treatment of mild to moderate vascular dementia,and its effects on serum superoxide dismutase（ SOD） activity and malondialdehyde（ MDA） content. Methods： 60 cases of mild to moderate vascular dementia patients were divided into treatment group and control group,30 cases in each group. The treatment group was given NBP for 8 weeks,while the control group was treated with Piracetam for 8 weeks. The mini mental state examination（ MMSE）,activity of daily living scale（ ADL） and clinical dementia rating（ CDR） were used to assess the clinical effects,and the SOD activity and MDA content were detected. Results： After the treatment,the scores of MMSE and ADL of treatment group significantly increased than those before the treatment,and the differences were significant（ P〈0. 05）. There were no statistical differences in the SOD activity and MDA content before and after the treatment（ P 〉0. 05）. Conclusions： n-Butylphthalide can effectively improve the clinical efficacy of the vascular dementia patients and improve the quality of life.