颅外动静脉畸形血管生成的研究进展

Research Progress of Neovascularization in Extracranial Arteriovenous Malformation

颅外动静脉畸形(Extracranial arteriovenous malformation,AVM)是一种动静脉异常沟通的血管畸形,AVM的发生发展机制尚未明确,目前认为血流动力学改变和体内激素水平升高可能在其中起着重要作用。众多研究发现,包括血管新生(Angiogenesis)和血管发生(Vasculogenesis)在内的血管生成也参与了AVM的发生和发展过程,并可能具有重要作用。本文对AVM发生发展过程中血管生成的研究进展进行综述。

Extracranial arteriovenous malformations （AVMs） are considered an abnormal communication between feeding arteries and draining veins without intervening capillaries. Although hemodynamic change and the increase of hormone level are considered playing an important role in the occurrence and development of AVMs, neovascularization including angiogenesis and vasculogenesis also participate in the occurrence and development of AVMs demonstrated by many researches. In this paper, the research progress of neovascularization in extracranial arteriovenous malformation was reviewed.