摘要
目的了解河南省1~4岁儿童乙型肝炎（乙肝）表面抗原（HBsAg）携带率,评价乙肝免疫效果。方法采用多阶段随机抽样的方法,按照经济水平和城乡两个因素进行抽样,对调查对象进行问卷调查和采集3ml血样,采用酶联免疫吸附试验（ELISA）检测HBsAg、乙肝核心抗体（HBc Ab）、乙肝e抗体（HBe Ab）和乙肝e抗原（HBeAg）,分析疫苗的保护效果。结果共调查1~4岁儿童5 474人,HBsAg携带率为0.45%,HBc Ab阳性率为2.23%。在HBsAg阳性的儿童中,34.6%（9/26）的调查对象HBeAg为阳性,46.2%（12/26）的调查对象HBe Ab为阳性。结论实施免疫规划以来,河南省5岁以下儿童的HBsAg携带率已经下降到0.5%以下,实现了世界卫生组织提出的西太地区5岁以下儿童2017年HBsAg携带率低于1%的目标。
Objective To determine the carriage rate of hepatitis B surface antigen（ HBsAg） among children 1 to 4 years old in Henan,and to evaluate the impact of hepatitis B immunization strategies.Methods We conducted a multi-stage,random-sample survey.A total of 5 474 children,aged 1-4 years,were selected for detection of HBsAg,hepatitis B core antibody（ HBc Ab）,hepatitis B e antibody（ HBe Ab）,and hepatitis B e antigen（ HBeAg） using enzyme-linked immunosorbent assays（ ELISA）.Results Among children aged 1-4 years old,the HBsAg carriage rate and the HBc Ab positive rate were 0.45% and2.23%,respectively.The HBeAg carriage rate and the HBe Ab positive rate among HBsAg-positive children were 34.6%（ 9/26） and 46.2%（ 12/26）,respectively.Conclusions The carriage rate of HBsAg or hepatitis B virus（ HBV） infectious rate declined significantly since the hepatitis B vaccine（ Hep B） was introduced into the Expanded Program on Immunization in 1992.Carriage rates were lower than the Western Pacific Region of World Health Organization＇s target of 1% among children 5 years old by 2017.
出处
《中国疫苗和免疫》
北大核心
2016年第3期259-262,共4页
Chinese Journal of Vaccines and Immunization
