陕西省西安市2013年健康人群麻疹抗体水平调查分析

Antibody Levels against Measles among a Healthy Population in Xi'an City of Shaanxi Province,2013

目的了解西安市健康人群麻疹免疫状况,有针对性地开展麻疹的科学防治。方法采用分层整群抽样的方法,于2013年选择8月龄~40岁健康人群作为调查对象,采用酶联免疫吸附试验（ELISA法）检测麻疹IgG抗体水平。结果共调查1 463人,其中麻疹IgG抗体阳性1 349人,抗体阳性率为92.2%,几何平均浓度（GMC）为1 278.6 m IU/ml。8月龄~2岁年龄组IgG抗体阳性率最高（95.8%）,3~4岁年龄组IgG抗体阳性率最低（88.4%）。常住人口的IgG抗体阳性率显著高于流动人口。接种1剂次和2剂次以上含麻疹成分疫苗（MCV）人群的IgG抗体阳性率显著高于未接种人群。结论西安市健康人群的麻疹抗体阳性率较高,应关注3~10岁年龄段儿童和流动人口的MCV免疫接种工作。

Objective To determine measles immunity among a healthy population in Xi＇an,and to improve measures of measles prevention.Methods Using multi-cluster sampling methods,we selected healthy subjects 8 months to 40 years of age in 2013 and tested measles IgG antibody levels by enzyme-linked immunosorbent assay（ ELISA）.Results Among a total of 1 463 subjects,1 349 were positive for measles antibody,for a positivity rate of 92.2%.The geometric mean antibody concentration（ GMC） was 1 278.6m IU/ml.The highest positivity rate（ 95.8%） was seen in children aged 8 months to 2 years,and the lowest rate（ 88.4%） was seen in children 3 to 4 years of age.The antibody positivity rate in the locally-registered population was significantly higher than in the migrant population.The antibody positivity rate among those vaccinated with ≥1 doses of measles-containing vaccine was significantly higher than among those not vaccinated.Conclusions The positivity rate of measles antibody was high in Xi＇an.We should pay attention to immunization rates among 3-10 year old children and among the migrant population.