上海市某区老年人肺炎链球菌血清抗体水平调查

Seroprevalence of Antibodies against Streptococcus pneumoniae among the Elderly in a District of Shanghai

目的了解上海市某区无肺炎疫苗免疫史的老年人肺炎链球菌血清抗体水平,探寻老年人肺炎链球菌抗体水平可能的影响因素。方法选择2013年7月底至11月中旬体检的60岁以上无肺炎疫苗免疫史的老年人开展问卷调查,并采集血清检测肺炎链球菌抗体。采用Logistic回归方法分析影响肺炎链球菌抗体水平的因素。结果在590名老年人中,肺炎链球菌抗体总阳性率为7.3%;其中吸烟者和非吸烟者分别为4.5%、7.6%,有、无哮喘者分别为12.5%、7.1%,2012年起患过、未患肺炎者分别为7.7%、7.3%;最近一年有、无感冒史者分别为9.3%、5.9%。Logistic回归分析未发现调查的相关因素对肺炎链球菌抗体阳性率有显著影响。结论全区无肺炎疫苗免疫史的老年人肺炎链球菌抗体阳性率整体处于较低水平。

Objective To determine antibody levels against Streptococcus pneumoniae among elderly people in a district of Shanghai who had not received pneumococcal vaccine.Methods Unvaccinated people over 60 years old who had physical examinations between July and November,2013 were invited to be interviewed;blood samples were collected for testing pneumococcal Ig G antibody levels.A logistic analytical model was used to determine factors influencing antibody levels.Results Among a total of 590 subjects,the positive rate of pneumococcal Ig G antibody was 7.3%.The positivity rates were 4.5% in smokers and 7.6% in non-smokers;12.5% in people with asthma and 7.1% in people without asthma;7.7% in people who ever had pneumonia since 2012 and 7.3% in people who did not have pneumonia since 2012;and 9.3% in people who had cold in the past year and 5.9% in people did not have cold in the past year.No factors were found to be significantly associated with pneumococcal Ig G antibody.Conclusions The positive rate of pneumococcal Ig G antibody was low among the elderly who did not receive pneumococcal vaccine in the district.