维吾尔族2型糖尿病与GCKR基因多态性的相关性

Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs

目的研究葡萄糖激酶调节蛋白（glucokinaseregulatorprotein，GCKR）基因rs780094位点多态性与新疆维吾尔族人群2型糖尿病（type2diabetes，T2D）的关系。方法采用病例一对照研究，在Sequenom技术平台上对维吾尔族1006例T2D患者和1004名正常对照GCKR基因rs780094位点进行基因分型，用Logistic回归分析rs780094位点多态性与新疆维吾尔族人群T2D的关系。结果GCKR基因rs780094位点等位基因和基因型分布在新疆维吾尔族人群T2D组和对照组间的差异无统计学意义（P〉0．05）；调整混杂因素后，Logistic回归分析显示，rs780094位点在加性模型和显性模型下可见与T2D的相关趋势（OR=1．181，95％CI：1．021～1．366，P=0．025；OR=1．296，95％CI：1．043～1．610，P=0．019）；AA基因型携带者总胆固醇水平较GA、GG基因型携带者高（P〈O．05）。结论维吾尔族人群中GCKR基因rs780094位点多态性与T2D的发生有关，AA基因型可能增加T2D的发病风险。

Objective To assess the association of glucokinase regulator protein （GCKR） gene polymorphisms and type 2 diabetes （T2D） among ethnic Uygurs from Xinjiang, China. Methods One thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system. Results The distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups （P〉0. 05）. After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model （OR=I. 181, 95%CI=1. 021-1. 366, P=0. 025; OR=I. 296, 95%CI： 1. 043-1. 610, P= 0. 019）. The total cholesterol level was higher in AA carriers than GG and GA carriers （P〈0. 05）. Conclusion The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.