端粒保护蛋白TPPl的功能及其与肿瘤特征相关性的研究进展

Advance in research on the function of telomeric shelterin component TPP1 and its relationship withcharacteristics of tumors

TPP1是一种重要的端粒保护蛋白，它与其他5个核心蛋白（POT1、TRF1、TRF2、TIN2、Rapl）通过一系列的相互作用，共同形成端粒保护蛋白复合体（sheherin）以维持端粒结构、功能的稳定性和完整性。近年来随着对TPP1研究的深入，其对端粒的保护机制以及对端粒酶活性的调节作用被进一步明确。此外，TPPl在肿瘤的发生、发展和治疗等过程中的作用也日益凸显。为了更好地理解和深入探讨TPP1与肿瘤的关系，我们就TPP1的结构、功能、及其与其它相关蛋白的作用以及与肿瘤特征相关性的研究进行综述。

As an important telomere binding protein, TPP1 protects the ends of telomeres and maintains the stability and integrity of its structure and function by interacting with other five essential core proteins （POT1, TRF1, TRF2, TIN2, and RAP1） to form a complex called Shelterin. Recently, researchers have discovered that TPP1 participates in protection of telomeres and regulation of telomerase activity. The relationship between TPP1 and tumorigenesis, tumor progression and treatment have also been investigated. This paper reviews the latest findings of TPP1 regarding to its structure, function and interaction with other proteins involved in tumorigenesis.