尤瑞克林联合法舒地尔治疗短暂性脑缺血发作疗效的观察

Efficacy of kallikrein combined with fasudil for the treatment of transient ischemic attack

目的分析尤瑞克林联合法舒地尔治疗短暂性脑缺血发作的疗效。方法选取我院2014年6月-2015年6月130例短暂性脑缺血发作患者按照数字抽签法,130例患者分为对照组和试验组两组。其中,对照组采取常规治疗,试验组采取常规治疗联合尤瑞克林＋法舒地尔,比较两组的总有效率、住院时间、住院费用、治疗前后患者神经功能缺损症状持续时间、发作次数、发作频率以及90d内发生脑梗死发生率。结果跟对照组比较,试验组总有效率更高,住院时间、住院费用更少,治疗后神经功能缺损症状持续时间、发作次数、发作频率明显减少,90d内发生脑梗死发生率更低,差异有统计学意义（P〈0.05）。结论尤瑞克林联合法舒地尔治疗短暂性脑缺血发作效果确切,可有效改善患者发作症状和缩短发作时间,缩短住院时间,减轻住院治疗负担,且远期预防脑梗死的效果较好,值得推广。

Objective To Analyze the curative effect of Kallikrein combined with fasudil for the treatment of transient ischemic attack. Methods 130 transient ischemic attack patients were selected according to the number of lottery from June 2014 to 2015 June in our hospital. The 130 patients were divided into control group and test group. Patients in the control group were treated with conventional therapy, and patients in the test group were treated with conventional therapy combined with kallikrein ＋ fasudil. The indexes of total effective rate, length of stay, hospital costs, duration of neurological deficits and symptoms in patients before and after treatment, attack times, seizure frequency and the incidence of cerebral infarction occurred within 90 d were compared between the two groups. Results Compared with the control group, the total effective rate of test group was higher, length of stay and hospital costs were less, the duration of neurological deficits and symptoms in patients after treatment, attack times and seizure frequency were significantly reduced, the incidence of cerebral infarction occurred within 90 d was lower（P〈0.05）.There was statistical significance. Conclusion The effects of kallikrein combined with fasudil for the treatment of transient ischemic attack were exact, which could effectively improve the patient＇s symptoms and shorten the time of attack,could shorten the length of stay, could reduce the burden of hospitalization, and long-term effect of cerebral infarction was better, it was worth promoting.