葛根素注射液联合依达拉奉治疗脑梗死的临床研究

Clinical study on puerarin injection combined with edaravone in treatment of cerebral infarction

目的探讨葛根素注射液联合依达拉奉治疗脑梗死的临床效果。方法脑梗死患者164例采用随机数字表法分为两组。对照组患者82例采用依达拉奉注射液治疗。观察组患者82例采用葛根素注射液联合依达拉奉注射液治疗。比较两组患者的检测指标、评定结果、治疗情况、药物不良反应情况。结果治疗后,两组患者检测指标(肿瘤坏死因子α、白介素-6、C反应蛋白、梗死体积)和相关评分(CSS评分、NIHSS评分)降低(P<0.05)。两组患者相关评分(MAS评分、ADL评分)增加(P<0.05)。观察组患者检测指标(肿瘤坏死因子α、白介素-6、C反应蛋白、梗死体积)和相关评分(CSS评分、NIHSS评分)低于对照组(P<0.05)。观察组患者相关评分(MAS评分、ADL评分)、治疗总有效率高于对照组(P<0.05)。结论葛根素注射液联合依达拉奉治疗脑梗死的疗效显著,可减轻机体炎症反应,改善神经功能。

Objective To investigate clinical effect of puerarin injection combined with edaravone in treatment of cerebral infarction. Methods 164 cases of patients with cerebral infarction were divided into two groups by random number table method.82 patients were divided into control group,who were received edaravone injection treatment.82 patients were divided into observation group,who were received puerarin injection combined with edaravone injection treatment.Detection indexes,evaluation results, treatment situation and adverse drug reactions were compared between the two groups. Results After the treatment, detection indexes（tumor necrosis factorα,interleukin-6,C reactive protein,Infarct volume）and Correlation scores（CSS score,NIHSS score）of the patients in two groups were all decreased（P 0.05）.Relative scores（MAS score,ADL score）was increased in two groups（P 0.05）.Detection indexes（tumor necrosis factorα,interleukin-6,C reactive protein, infarct volume） and relative scores（CSS score,NIHSS score）in observation group were lower than those in control group（P 0.05）. Conclusion Puerarin injection combined with edaravone has significant effect in treatment of cerebral infarction, and it can relieve inflammatory reaction and improve nerve function.