宫腔内持续放置水囊联合大剂量雌激素对宫腔粘连分离术后再粘连的预防价值

Preventive value of uterus cavity continuing water capsule placement combined large dose estrogen for postoperative readhesion of adhesions transcervical resection

目的探讨宫腔内持续放置水囊联合大剂量雌激素对宫腔粘连分离术后再粘连的预防价值。方法选取我院宫腔粘连患者79例,随机分为两组,全部患者均采用宫腔粘连分离术,观察组术后采用宫腔内持续放置水囊联合大剂量雌激素治疗;对照组术后采用宫腔内持续放置水囊联合低剂量雌激素治疗,比较两组宫腔粘连分离术后再粘连发生率的差异。结果两组患者术后再粘连发生率比较差异无统计学意义(P>0.05),观察组月经恢复正常率与术后1年妊娠率明显高于对照组比较差异有统计学意义(P<0.05),手术前后,全部患者凝血功能指标未见异常改变,差异无统计学意义(P>0.05)。两组患者均无严重的药物不良反应。结论宫腔内持续放置水囊联合大剂量雌激素有助于改善宫腔粘连分离术后患者的月经恢复与妊娠结局情况,但对宫腔粘连分离术后再粘连无明显影响。

Objective To explore the preventive value of uterus cavity continuing water capsule placement combined large dose estrogen for postoperative re-adhesion of adhesions transcervical resection. Methods 79 intrauterine adhesion patients which treated in our hospital were selected and randomly divided into two groups,all patients were adopted adhesions transcervical resection,observation group were given continuing water capsule placement combined large dose estrogen,control group were given continuing water capsule placement combined low dose estrogen, the postoperative re-adhesion rate of adhesions transcervical resection were compared between the two groups. Results Postoperative re-adhesion rate between the two group were compared,and had no significant difference（P 0.05）,menstrual recovery rate and post-oprative 1year pragant rate of observation group were significantly higher than control group（P 0.05）.Before and after operation,No abnormal changes about blood coagulation function index of all patients were observed（P 0.05）.All patients of two groups were occurred no serious adverse drug reactions. Conclusion Uterus cavity continuing water capsule placement combined large dose estrogen can improve menstrual recovery and pregnancy outcome for postoperative patients of adhesions transcervical resection,but had no impact for postoperative re-adhesion of adhesions transcervical resection.