不同类型冠心病和血浆同型半胱氨酸水平相关性研究及价值

The research and value of correlation between different types of coronary heart disease and plasma homocysteine levels

目的研究探讨不同类型冠心病和血浆同型半胱氨酸水平相关性,为冠心病的诊治提供指导。方法将所选取150例胸痛患者,进行冠心病以及相关生化指标的检查,将结果进行统计并对比。结果不同时期的冠心病,其同型半胱氨酸水平具一定规律性。心绞痛患者其水平有所升高,急性心肌梗死发生时,同型半胱氨酸水平升至最高。当病情发展至陈旧性心肌梗死时,其水平则下降至心绞痛相同水平。合并高血压、糖尿病、高胆固醇血症以及吸烟的患者,其同型半胱氨酸水平明显高于未有此类合并症的患者。经分析,均具有统计学意义(P<0.01)。结论冠心病不同时期以及其合并症情况,与血浆同型半胱氨酸水平具有一定相关性,可根据同型半胱氨酸水平,综合分析患者其他生化指标,提高对疾病诊治的准确性。

Objective To research and explore the correlation between different types of coronary heart disease and plasma homocysteine levels was to provide guidance for diagnosing and treating coronary heart disease. Methods 150 patients with chest pain were selected to receive coronary heart disease and related biochemical examination, the results were statistically compared. Results The homocysteine level of coronary heart disease in different periods had certain regularity. The homocysteine level of patients with angina pectoris increased, when the acute myocardial infarction occurred, the homocysteine levels rose to the highest. As the disease developed to remote myocardial infarction, this level decreased to the same level of angina pectoris. The homocysteine level of hypertension, diabetes, hypercholesterolemia and smoking patients was significantly higher than that of patients with no such complications. After analysis, there was statistically significant（P〈 0.01）. Conclusion Coronary heart disease in different periods and its complications were relevant with the plasma homocysteine levels. Doctors could comprehensively analyze other biochemical indexes of patients according to the homocysteine levels, which helped to improve the accuracy of diagnosing and treating disease.