不同抗菌药物方案治疗成人下呼吸道感染的疗效观察

Curative effect observation of different antimicrobial schemes in treatment of lower respiratory tract infection in adult

目的探讨不同抗菌药物方案治疗成人下呼吸道感染的疗效。方法选择我院呼吸科2013年12月-2014年12月收治的240例下呼吸道感染患者作为研究对象,按照随机数字表法将患者分为A、B、C三组各80例,A组患者应用左氧氟沙星,B组应用阿奇霉素,C组应用头孢呋辛钠,比较三组患者的疗效,并进行成本-效果分析。结果 A组患者的总有效率为86.25%,B组率为87.50%,C组为88.75%,三组患者疗效比较,差异无统计学意义（P〉0.05）;三组患者均未发生明显不良反应。A组的C/E值最小,其敏感度分析结果也表明A组应用的左氧氟沙星性价比更高。结论左氧氟沙星治疗成人下呼吸道感染效果较好,且无明显不良反应,性价比较高,值得临床推广应用。

Objective To explore the curative effect of different antimicrobial schemes in treatment of lower respiratory tract infection in adult. Methods 240 cases of patients with lower respiratory tract infection cured in department of respiration of our hospital from December 2013 to December 2014 were selected as the study objects and divided into group A,group B and group C with 80 cases in each according to random number table method.Patients in group A were treated with levofloxacin,patients in group B were treated with azithromycin,and patients in group C were treated with cefuroxime sodium.Curative effects of the three groups were compared,and the cost-effectiveness analysis was carried on. Results Total effective rates of group A,group B and group C were respectively 86.25%,87.5% and 88.75%.There was no significant difference in the curative effect between the 3 groups（P 〉0.05）,and no obvious adverse reactions occurred in the three groups.The value of C/E of group A was the smallest.The sensitivity analysis results also showed that levofloxacin of group A was more cost-effective. Conclusion The effect of levofloxacin in treatment of lower respiratory tract infection in adult is good with no obvious adverse reactions and high cost-effective.It is worthy of clinical popularization and application.