老年乳腺癌的临床病理特点与分子分型

The Pathological Characteristics and Molecular Subtypes of Breast Cancer of Elderly Patients

目的：探讨老年女性乳腺癌患者的临床特点、分子分型。方法：回顾性分析山西省人民医院2010年2月~2015年2月收治的65例老年（≥65岁）女性乳腺癌患者的临床资料,随机选取同期青年（≤35岁）女性乳腺癌患者78例作为对照组,对比分析两组患者临床病理特征以及合并症情况。结果：老年组乳腺癌患者T1期T2期居多,临床分期以Ⅱ期所占比例最高69.23%,淋巴结转移率低41.54%,ER、PR阳性率高、Her-2阴性率高,Luminal A型所占比例高,TNBC比例低,差异有统计学意义（P〈0.05）。老年组乳腺癌患者合并症多,手术治疗个体化,化疗比例低,内分泌治疗比例高。结论：老年乳腺癌具有独特的生物学特性,治疗应选择以手术为主的综合治疗,其中内分泌治疗占重要地位。

Objective：To explore the clinical features and treatment of old women with breast cancer. Methods： The clinical date of 65 female cases of age≥65 years with breast cancer who were treated in Shanxi Provincal People＇s Hospital from February ,2010 to February ,2015 were retrospectively ananlyzed and compared with those of 78 female cases with breast cancer of age ≤ 35 years as control group selected randomly during the same period. The pathological characteristics and therapies were compared. Results： The number of Ⅰ ,Ⅱ stage breast cancer patients in elderly group were significantly higher. The highest proportion was Ⅱ stage（69.23% ）. The rate of lymph node metastasis was lower, 41.54%. ER positive rate and PR positive rate was higher. Her-2 negative rates was higher. The proportion of Luminal A type was higher and the triple-negative breast cancer（ TNBC ） was lower. The difference was statistically significant （ P 〈 0.05 ）. The rate of breast endocrine therapy was higher. The rate of breast chemical therapy was lower. Conclu- sion： Breast cancer in elderly patients has distinct biological characteristic. Surgery should be choosen as the main meth- od of combined treatment , in which hormonal therapy plays an important role.