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肾脏肌醇加氧酶在糖尿病肾病小管损伤中的作用与机制研究进展 被引量：1

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摘要 糖尿病肾病（DN）是一种与代谢异常密切相关的疾病。肌醇（MI）是维生素B族中的一种亲脂性维生素，其主要功能包括维持细胞生长和存活，调节神经细胞发育与骨细胞代谢，降低胰岛素抵抗，增加高密度胆固醇，降低低密度胆固醇及三酰甘油水平，维持线粒体形态与功能，改变钠钾泵活性，清除活性氧等。
作者 符晓 刘煜 胡纯 肖力 刘伏友 孙林
机构地区 中南大学肾脏病研究所、湖南省血液净化与肾脏病重点实验室、中南大学湘雅二医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2016年第7期548-551,共4页 Chinese Journal of Nephrology
基金 国家自然科学基金（81270812、81370832、81470960、81570658）
关键词 糖尿病肾病 肌醇 加氧酶 维生素B族 损伤 肾脏 神经细胞发育 高密度胆固醇
分类号 R587.2 [医药卫生—内分泌]
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参考文献29

  • 1Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases[J]. Biochimie, 2013, 95 (10): 1811-1827.
  • 2Nascimento NR, Lessa LM, Kerntopf MR, et al. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide [J]. Proc Natl Acad Sci USA, 2006,103(1): 218- 223.
  • 3Brown PM, Caradoc- Davies 33", Dickson JM, et al. Crystal structure of a substrate complex of myo-inositol oxygenase, a di- iron oxygenase with a key role in inositol metabolism[J]. Proc Natl Acad Sci USA, 2006, 103(41): 15032- 15037.
  • 4Gaut JP, Crimmins DL, Ohlendorf MF, et al. Development of an immunoassay for the kidney- specific protein myo- inositol oxygenase, a potential biomarker of acute kidney injury[J]. ClinChem, 2014, 60(5): 747- 757.
  • 5Yang Q, Dixit B, Wada J, et al. Identification of a renal-specific oxido- reductase in newborn diabetic mice[J]. Proc Natl Acad Sci USA, 2000, 97(18): 9896- 9901.
  • 6Hu E, Chen Z, Fredrickson T. Identification of a novel kidney- specific gene downregulated in acute ischemic renal failure[J]. Am J Physiol Renal Physiol, 2000, 279(3): F426-F439.
  • 7Nayak B, Xie P, Akagi S, et al. Modulation of renal- specific oxidoreductase/myo- inositol oxygenase by high- glucose ambience[J]. Proc Natl Acad Sci USA, 2005, 102(50): 17952- 17957.
  • 8Arner R J, Prabhu KS, Reddy CC. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney[J]. Biochem Biophys Res Commun, 2004, 324 (4): 1386-1392.
  • 9DOh lO.lO16/j.bbrc,2004.09,209. Nayak B, Kondeti VK, Xie P, et al. Transcriptional and post- translational modulation of myo- inositol oxygenase by high glucose and related pathobiological stresses[J]. J Biol Chem, 2011, 286(31): 27594-27611.
  • 10Tominaga T, Dutta RK, Joladarashi D, et al. Tanscriptional and translational modulation of myo- inositol oxygenase (miox) by fatty acids: implications in renal tubular injury induced in obesity and diabetes[J]. J Biol Chem, 2016, 291(3): 1348-1367.

二级参考文献15

  • 1吴珺,鲁一兵,缪珩,许旌.选择性血管紧张素Ⅱ受体拮抗剂对糖尿病大鼠血管单核细胞趋化蛋白-1表达的影响[J].南京医科大学学报（自然科学版）,2007,27(2):145-149. 被引量：4
  • 2Xia L,Wang H,Munk S,et al. High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF- beta1 signaling in mesangial cells [J]. Am J Physiol Renal Physiol, 2008,295 (6) : F1705-F1714.
  • 3Petersen M,Thorikay M;Deckers M,et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis [J]. Kidney Int,2008,73 (6) :705-715.
  • 4Yang Q, Dixit JB,Wada J,et al. Identification of a renal specific oxido- reductase in newborn diabetic mice [J]. Proc Nat Acad Sci USA, 2000,97 (18) : 9896-9901.
  • 5Amer RJ,Prabhu KS, Krishnan V,et al. Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications [J]. Biochem Biophys Res Commun, 2006, 339 (3): 816-820.
  • 6Nayak B, Xie P, Akagi S, et al. Modulation of renalspecific oxidoreductase/myo-inositol oxygenase by high- glucose ambience [J]. Proc Nat Acad Sci USA, 2005, 102(50) : 17952-17957.
  • 7Danesh FR, Wada J, Wallner EI, et al. Gene regulation of aldose-, aldehyde and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitus [J]. Curt Med Chem, 2003, 10(15): 1399-1406.
  • 8Prabhu KS, Arner R J, Vunta H, et al. Up-regulation of human myo- inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells [J]. J Biol Chem, 2005, 280(20) : 19895-19901.
  • 9Wu D, Peng F, Zhang B, et al. PKC-betal mediates glucose-induced Akt activation and TGF-betal upregulation in mesangial cells [J]. J Am Soc Nephrol, 2009, 20 (3) : 554-566.
  • 10Luo P, Zhou Y,Chang HH,et al. Glomerular 20-HETE, EETs, and TGF-{beta} 1 in diabetic nephropathy [ J ]. Am J Physiol Renal Physiol, 2009,296 (3) : F556-F563.

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中华肾脏病杂志
2016年 第7期

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