期刊文献+

Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function

原文传递
导出
摘要 Regulatory T cells (Tregs) comprise a subset of CD4+ T lymphocytes that holds promise as immunotherapy for inflammat- ory disease states including autoimmune disorders, solid organ allograft rejection, graft-versus-host disease, and acute inflam- matory conditions. However, limited availability of Treg numbers restricts their usefulness in cell transfer applications, particularly as patients may need multiple infusions for chronic diseases. Regulatory T cells (Tregs) comprise a subset of CD4+ T lymphocytes that holds promise as immunotherapy for inflammat- ory disease states including autoimmune disorders, solid organ allograft rejection, graft-versus-host disease, and acute inflam- matory conditions. However, limited availability of Treg numbers restricts their usefulness in cell transfer applications, particularly as patients may need multiple infusions for chronic diseases.
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2016年第4期415-417,共3页 中国免疫学杂志(英文版)
  • 相关文献

参考文献9

  • 1Singer BD, King LS, D'Alessio FR. Regulatory T cells as immunotherapy. Front Immuno12014; 5: 46.
  • 2Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM etal. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med2007; 13: 1299-1307.
  • 3Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T etal. FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 2015; 125:1111-1123.
  • 4Wang L, de Zoeten EF, Greene MI, Hancock WW. Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov2009; 8: 969-981.
  • 5Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P et al. Unraveling the hidden catalytic activity of vertebrate class Ila histone deacetylases. Proc Natl Acad Sci U S A 2007; 104: 17335-17340.
  • 6Bradner J E, West N, Grachan ML, Greenberg EF, Haggarty S J, Warnow T et al. Chemical phylogenetics of histone deacetyiases. Nat Chem Bio12010; 6: 238-243.
  • 7Fischle W, Dequiedt F, Hendzel M J, Guenther MG, Lazar MA, Voelter Wet al. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 2002; 9: 45-57.
  • 8Chauhan SK, Saban DR, Lee HK, Dana R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol 2009; 182: 148-153.
  • 9Thapa P, Das J, McWilliams D, Shapiro M, Sundsbak R, Nelson-Holte Met al. The transcriptional repressor NKAP is required for the development of iNKT cells. Nat Commun 2013; 4: 1582.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部