小剂量咪达唑仑联合丙泊酚在ICU机械通气患者镇静治疗中的应用效果被引量：4

Application effect of small dose midazolam and propofol in sedation treatment of patients undergoing mechanical ventilation in ICU

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摘要目的探讨小剂量咪达唑仑联合丙泊酚在ICU机械通气患者镇静治疗中的应用效果。方法选取2013年12月~2016年1月本院ICU收治的61例机械通气患者作为研究对象,随机分为A组、B组、C组。A组给予咪达唑仑,B组给予丙泊酚,C组给予小剂量咪达唑仑联合丙泊酚。比较三组的镇静效果、镇静前后生命体征变化、谵妄发生次数。结果 C组达到理想镇静目标所需时间显著短于A组和B组,达到RASS评分-2^+1分的次数所占百分比显著高于A组和B组,差异有统计学意义(P<0.05)。三组镇静前后的RR、HR、SpO_2、MAP水平比较,差异有统计学意义(P<0.05)。三组镇静前后的Pa CO2水平比较,差异无统计学意义(P>0.05)。C组的谵妄阳性次数显著低于A组和B组,差异有统计学意义(P<0.05)。结论小剂量咪达唑仑联合丙泊酚在ICU机械通气患者中的镇静治疗效果及安全性优于咪达唑仑或丙泊酚单药镇静治疗,值得临床推广应用。 Objective To investigate the application effect of small dose midazolam and propofol in sedation treatment of patients undergoing mechanical ventilation in ICU.Methods 61 patients undergoing mechanical ventilation in ICU of our hospital from December 2013 to January 2016 were selected and randomly divided into group A,group B and group C.Group A was given midazolam,group B was given propofol,group C was given small dose midazolam and propofol. Sedative effect,the change of vital signs before and after sedation,occurrence of delirium among three groups was compared respectively.Results The time of achieving ideal sedation in group C was shorter than that in group A and group B,the percentage of the RASS score reached -2-＋1 points in group C was higher than that in group A and group B,with significant difference （P〈0.05）.There was significant difference in the level of RR,HR,SpO2,MAP before and after sedation among three groups （P〈0.05）.There was no significant difference in the level of PaC02 before and after sedation among three groups （P〉0.05）.The number of positive delirium in group C was lower than that in group A and group B, with significant difference （P〈0.05）.Conclusion The effect and safety of small dose midazolam combined with propofol in ICU mechanical ventilation patients are superior to midazolam or propofol alone,it is worthy of clinical promotion and application.

作者张鹏魏鹏

机构地区山东省淄博市第七人民医院重症医学科

出处《中国当代医药》 2016年第20期126-128,共3页 China Modern Medicine

关键词重症监护室机械通气镇静咪达唑仑丙泊酚 Intensive care unit Mechanical ventilation Sedation Midazolam Propofol

分类号 R614.24 [医药卫生—麻醉学]

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参考文献15

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