儿童腹型肥胖与体内炎性因子水平及代谢综合征的关系研究

Study on the relationship between abdominal obesity and the levels of inflammatory factors and metabolic syndrome in children

目的分析腹型肥胖与体内炎性因子水平及代谢综合征（MS）之间的关系，探讨儿童腹型肥胖的科学治疗方法。方法以该院儿科门诊2014年1月-2015年12月接诊的128例单纯性肥胖儿童为研究对象，根据腰围数据进行划分，设腹型组与非腹型组两组。同时对研究对象的体重、身高、臀围（H）、腰围（W）进行测量。采集各研究对象的空腹血并检测其血糖、血脂、超敏C反应蛋白（Hs-CRP）和内脂素水平。结果腹型组体质指数（BMI）、W、腰臀比（WHR）均明显高于非腹型组差异有统计学意义（t=4．85、3．82、3．08，均P〈0．05）；腹型组MS检出率明显高于非腹型组，差异有统计学意义（x^2=12．119，P〈0．05）；腹型组Hs—CRP及内脂素水平明显高于非腹型组，差异有统计学意义（t=4．612、4．121，均P〈0．05）；两组高血压、高血糖、高甘油三酯（TG）血症、低高密度脂蛋白胆固醇（HDL—C）血症的人数比较差异均有统计学意义（x^2=8．82、9．15、14．71、7．41，均P〈0．05）。结论在肥胖儿童中，较之非腹型肥胖儿童，腹型肥胖儿童MS患病几率更高；儿童腹部脂肪分布与体内炎症因子及TG的增高有着密切关系。因此，应对腹型肥胖进行积极防治。

Objective To analyze the relationship between abdominal obesity and the levels of inflammatory factors and metabolic syndrome( MS),explore the scientific treatment of abdominal obesity in children. Methods A total of 128 children with simple obesity were selected from Outpatient of Pediatrics in the hospital from January 2014 to December 2015,then the children were divided into abdominal obesity group and non- abdominal obesity group according to waist circumference. Body weight,height,hip circumference,and waist circumference were measured. Fasting blood samples were collected,blood glucose,blood lipids,hypersensitive C- reactive protein( hs- CRP),and visfatin levels were detected. Results Body mass index( BMI),waist circumference,and waist- to- hip ratio( WHR) in abdominal obesity group were statistically significantly higher than those in non- abdominal obesity group( t = 4. 85,3. 82,3. 08,P < 0. 05). The detection rate of MS in abdominal obesity group was statistically significantly higher than that in non- abdominal obesity group( χ2= 12. 119,P < 0. 05). The levels of hs- CRP and visfatin in abdominal obesity group were statistically significantly higher than those in non- abdominal obesity group( t = 4. 612,4. 121,P < 0. 05). There were statistically significant differences in the numbers of patients with hypertension,hyperglycemia,hypertriglyceridemia,high- density lipoprotein cholesterol hyperlipidemia between the two groups( χ2= 8. 82,9. 15,14. 71,7. 41,P < 0. 05). Conclusion Among the obese children,compared with non- abdominal obese children,the incidence rate of MS among abdominal obese children is higher; the distribution of abdominal lipids among children is closely correlated with inflammatory factors and increase of triglyceride level. Therefore,abdominal obesity should be prevented and treated actively.