法舒地尔治疗结缔组织病相关肺间质病变疗效观察

Clinical effect of fasudil in the treatment of interstitial lung disease associated with connective tissue disease

目的:观察法舒地尔对结缔组织病相关肺间质病变的治疗效果。方法:将62例结缔组织病肺间质病变患者随机分为对照组32例和治疗组30例。对照组行常规治疗,治疗组在常规治疗的基础上加用法舒地尔30 mg加入250 m L 0.9%氯化钠注射液静脉滴注,疗程14 d。对治疗前后行6 min步行实验、超声心动图测肺动脉压力、高分辨率胸部CT、血气分析及红细胞沉降率、C反应蛋白等进行对比。结果:用药后治疗组6 min步行距离增加,肺动脉压降低,高分辨率胸部CT评分降低,疾病活动度减轻,与用药前及对照组用药后差异均有统计学意义(P<0.01)。结论:法舒地尔治疗结缔组织病相关肺间质病变有效。

Objective： To observe the clinical effects of fasudil in the treatment of interstitial lung disease associated with connective tissue disease. Methods： Sixty-two patients with interstitial lung disease associated with connective tissue disease were randomly divided into the control group（ 32 cases） and treatment group（ 30 cases）. The control group were treated with conventional measures,and the treatment group were additionally treated with 30 mg fasudil based on the control group for 14 days. The 6-min walk test,pulmonary arterial pressure measured by echocardiography,high chest resolution CT and blood gas analysis and erythrocyte sedimentation rate and C reactive protein before and after treatment were compared. Results： After treatment,the 6-min walk distance increased,pulmonary artery pressure dropped,high resolution chest CT score decreased and activity reduced. The differences of whose between treatment group beforeand after treatment,and control group were statistically significant（ P〈0. 01）. Conclusions： The treatment of interstitial lung disease associated with connective tissue disease with fasudilis effective.