IL-12、IFN-γ、IL-10、IL-4和Th1/Th2在子痫前期孕妇血清中的表达水平及其意义

The serum levels of IL-12,IFN--γ,IL-10,IL-4 and Th1 / Th2in preeclampsia patients and its significance

目的:研究正常妊娠孕妇及子痫前期患者外周血中白细胞介素(IL)-12、γ干扰素(IFN-γ)、IL-10和IL-4的水平及临床意义,探讨辅助T细胞Th1/Th2细胞因子在子痫前期发病机制中的作用。方法:选择30例子痫前期孕妇(子痫前期组),同期住院分娩的无妊娠并发症的30例孕妇作为对照,检测2组孕妇血清中IL-12、IFN-γ、IL-10和IL-4含量并分析。结果:子痫前期组血清中的IL-12、IFN-γ蛋白水平及其mRNA含量均明显高于正常妊娠组(P<0.01),而IL-4、IL-10及其mRNA含量均显著低于正常妊娠组(P<0.01)。结论:Th1型细胞因子表达增加,Th2型因子减少以及Th1/Th2比例失衡可能是子痫前期发病的重要原因。

Objective： To explore the levels IL-12,IFN-γ,IL-10 and IL-4 in peripheral blood of normal pregnant women and preeclampsia patients and its clinical significance,and investigate the role of Th1 / Th2 cytokines of helper T cell in pathogenesis of preeclampsia. Methods： Thirty pregnant women with preeclampsia and 30 normal pregnant women without complications were divided into the observation group and control group,respectively. The serum levels of IL-12,IFN-γ,IL-10 and IL-4 in two groups were detected and analyzed. Results： The serum protein levels and mRNA expressions of IL-12 and IFN-γ in observation group were higher than that in control group（ P〈0. 01）. The serum protein levels and mRNA expressions of IL-4 and IL-10 in observation group were lower than control group（ P〈0. 01）. Conclusions： The type Th1 cytokine expression increasing,the Th2 expression decreasing and proportion imbalance of Th1 / Th2 may be the important causes of preeclampsia.