骨康胶囊联合透明质酸钠局部注射治疗骨性关节炎的疗效及安全性

Efficacy and safety of Gukang capsule combined with local injection of sodium hyaluronate in osteoarthritis

目的观察骨康胶囊联合透明质酸钠局部注射对骨性关节炎的临床效果及安全性。方法 2014年1月~2015年3月期间的69例骨性关节炎患者,按照双盲和随机的方法将所有患者分为对照组（n=35）和观察组（n=34）。对照组患者采用透明质酸钠局部注射联合氨基葡萄糖进行治疗,观察组患者使用透明质酸钠局部注射治疗联合骨康胶囊治疗。对治疗前后2组患者炎症因子白介素-1β（IL-1β）、肿瘤坏死因子（TNF-α）和超敏C反应蛋白（hs-CRP）水平进行测定和分析,对治疗前后2组患者骨关节功能评分、视觉模拟评分（visual analogue scale,VAS）、临床疗效和治疗过程中不良反应进行对比分析。结果观察组患者的TNF-α、IL-1β、hsCRP水平明显低于对照组（P〈0.05）;观察组患者的骨关节功能评分和VAS评分明显优于对照组（P〈0.05）;观察组治疗后总有效率明显高于对照组（χ^2=5.449,P〈0.05）;观察组患者治疗过程总不良反应率和对照组比较差异无统计学意义（χ^2=0.403,P〉0.05）。结论骨康胶囊联合透明质酸钠局部注射可降低骨性关节炎患者体内的炎症因子水平,治疗有效率高于传统治疗方案且不良反应少。

Objective To observe the efficaly and safety of Gukang capsule combined with local injection of sodium hyaluronate injection in the treatment of osteoarthritis. Methods 69 cases of osteoarthfitis from January 2014 to March 2015 were divided into control group （ n = 35 ） and observation group （ n = 34 ）, double-bhndly and randomly. The control group were treated with local injection of sodium hyaluronate combined with glucosamine treatment, the observation group were treated with sodium hyaluronate injection combined with Gukang capsule treatment. The inflammatory cytokines of interleukin-1 β（IL-1β）, tumor necrosis factor α （ TNF-α ） and ultra-sensitivity C-reactive protein （hs-CRP）, the bone and joint function score, VAS score, the clinical efficacy and adverse reactions before and after treatment between two groups were analyzed. Results The TNF-α, IL-1β, hs-CRP levels in observation group were significantly lower than the control group （ P 〈 0. 05 ） ; the bone and joint function score and VAS scores in observation group were significantly better than the control group （ P 〈 0. 05 ） ; the total efficacy in observation group was significantly higher than control group （χ^2 = 5. 449, P 〈 0. 05 ） ; there was no the total adverse reactions statistically significant between observation group and control group （χ^2= 0. 403, P 〉0. 05）. Conclusion The Gukang capsule combined with local injection of sodium hyaluronate could reduce inflammatory factors levels in the treatment of osteoarthritis patients, which is more efficient than traditional treatment regimens with few adverse reactions.